CAS 1227-61-8|Mefexamide

Introduction：Basic information about CAS 1227-61-8|Mefexamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Mefexamide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles4
8. Synonyms

Common Name	Mefexamide
CAS Number	1227-61-8	Molecular Weight	280.36
Density	1.0586 (rough estimate)	Boiling Point	460.4ºC at 760 mmHg
Molecular Formula	C₁₅H₂₄N₂O₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	232.2ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	N-[2-(diethylamino)ethyl]-2-(4-methoxyphenoxy)acetamide,hydrochloride
Synonym	More Synonyms

Mefexamide BiologicalActivity

Description	Mefexamide is a particular psychostimulant.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

Chemical & Physical Properties

Density	1.0586 (rough estimate)
Boiling Point	460.4ºC at 760 mmHg
Molecular Formula	C₁₅H₂₄N₂O₃
Molecular Weight	280.36
Flash Point	232.2ºC
PSA	50.80000
LogP	2.72490
Vapour Pressure	1.17E-08mmHg at 25°C
Index of Refraction	1.5800 (estimate)
InChIKey	HUNIPYLVUPMFCZ-UHFFFAOYSA-N
SMILES	CCN(CC)CCNC(=O)COc1ccc(OC)cc1
Storage condition	2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB7175000

CHEMICAL NAME :: Acetamide, N-(2-(diethylamino)ethyl)-2-(p-methoxyphenoxy)-

CAS REGISTRY NUMBER :: 1227-61-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H24-N2-O3

MOLECULAR WEIGHT :: 280.41

WISWESSER LINE NOTATION :: 2N2&2MV1OR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 1,444,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2702M

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMPYAT Annales Medico-Psychologiques. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1-Series 11, V.2, 1843-1921; V.80- 1922- Volume(issue)/page/year: 123,141,1965

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H310-H330
Precautionary Statements	P260-P264-P280-P284-P302 + P350-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+
Risk Phrases	26/27/28
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	AB7175000
HS Code	2924299090

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles4

[Correction of psychodepressive effects of benzodiazepine tranquilizers by administration of psychostimulants].

Biull. Eksp. Biol. Med. 94(10) , 48-51, (1982)

[Preliminary pharmacological investigations of six new p-chlorphenoxyacetic acid derivatives (author's transl)].

Ann. Univ. Mariae Curie. Sklodowska. Med. 34 , 259-68, (1979)

[Contribution to biotransformation and analysis of the psychopharmacon mefexamide (author's transl)].

Z. Rechtsmed. 87(1-2) , 117-27, (1981)

After oral administration of a therapeutic dosage (400 mg) Mefexamide (I), six excretion products were detected in human urine and subsequently identified by GC/MS and TLC: in addition to the unchange...

Synonyms

p-Methoxyphenoxyacetic acid 2-(diethylamino)ethylamide

p-Methoxyphenoxyacetic acid 2-[diethylamino]ethylamide

Mefexamide hydrochloride

4-Methoxy-phenoxyessigsaeure-<2-diethylamino-ethylamid>

N,N-Diethyl-N'-<(4-methoxy-phenoxy)-acetyl>-ethylendiamin

mefexamide

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