CAS 120550-35-8|Biotin-PFP ester

Introduction：Basic information about CAS 120550-35-8|Biotin-PFP ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameBiotin-PFP ester
CAS Number120550-35-8Molecular Weight410.359
Density1.4±0.1 g/cm3Boiling Point555.3±50.0 °C at 760 mmHg
Molecular FormulaC16H15F5N2O3SMelting Point190.0 to 194.0 °C
MSDS/Flash Point289.6±30.1 °C

Names

Name(2,3,4,5,6-pentafluorophenyl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
SynonymMore Synonyms

Biotin-PFP ester BiologicalActivity

DescriptionBiotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

Alkyl/ether

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Density1.4±0.1 g/cm3
Boiling Point555.3±50.0 °C at 760 mmHg
Melting Point190.0 to 194.0 °C
Molecular FormulaC16H15F5N2O3S
Molecular Weight410.359
Flash Point289.6±30.1 °C
Exact Mass410.072357
PSA92.73000
LogP2.85
Vapour Pressure0.0±1.5 mmHg at 25°C
Index of Refraction1.513
InChIKeyDKTMDBQDSYQUEV-LEJLMFORSA-N
SMILESO=C1NC2CSC(CCCCC(=O)Oc3c(F)c(F)c(F)c(F)c3F)C2N1
Storage condition2-8°C

Synonyms

biotin-pentafluoro-phenyl ester
Pentafluorophenyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate
D-biotin pentafluorophenyl ester
1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 2,3,4,5,6-pentafluorophenyl ester, (3aS,4S,6aR)-
(+)-Biotin-PFP-ester
biotinylpentafluorophenyl ester
Perfluorophenyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
PFP-Biotin
CAS 402855-01-0|N4-(3-Chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine
CAS 104966-97-4|10-HYDROXY-1-(2-HYDROXY-3,4-DIMETHOXY-6-METHYLPHENYL)DECAN-1-ONE
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