CAS 1185031-19-9|Pindolol-d7

Introduction：Basic information about CAS 1185031-19-9|Pindolol-d7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Pindolol-d7 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Pindolol-d7
CAS Number	1185031-19-9	Molecular Weight	255.36400
Density	/	Boiling Point	/
Molecular Formula	C₁₄H₁₃D₇N₂O₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1-(1,1,1,2,3,3,3-heptadeuteriopropan-2-ylamino)-3-(1H-indol-4-yloxy)propan-2-ol
Synonym	More Synonyms

Pindolol-d7 BiologicalActivity

Description	Pindolol-d7 (LB-46-d7) is the deuterium labeled Pindolol. Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33 nM)[1][2].
Related Catalog	Research Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Artigas F, et al. Pindolol augmentation of antidepressant response. Curr Drug Targets. 2006;7(2):139-147. [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

Molecular Formula	C₁₄H₁₃D₇N₂O₂
Molecular Weight	255.36400
Exact Mass	255.19600
PSA	57.28000
LogP	2.29650
InChIKey	JZQKKSLKJUAGIC-SVMCCORHSA-N
SMILES	[2H]C([2H])([2H])C([2H])(C([2H])([2H])[2H])NCC(COC1=CC=CC2=C1C=CN2)O

Synonyms

Apo-pindol

Pindolol-d7

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