CAS 1294048-82-0|Thiamethoxam-d3
| Common Name | Thiamethoxam-d3 | ||
|---|---|---|---|
| CAS Number | 1294048-82-0 | Molecular Weight | 294.733 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 485.8±55.0 °C at 760 mmHg |
| Molecular Formula | C8H7ClD3N5O3S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 247.6±31.5 °C |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | (NZ)-N-[3-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-(trideuteriomethyl)-1,3,5-oxadiazinan-4-ylidene]nitramide |
|---|---|
| Synonym | More Synonyms |
Thiamethoxam-d3 BiologicalActivity
| Description | Thiamethoxam-d3 is the deuterium labeled Thiamethoxam[1]. Thiamethoxam is a broad spectrum neonicotinoid insecticide[2][3]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Lobson C, et al. Fate of thiamethoxam in mesocosms and response of the zooplankton community. Sci Total Environ. 2018 Oct 1;637-638:1150-1157. [3]. Ludicke JC, et al. Thiamethoxam impairs honey bee visual learning, alters decision times, and increases abnormal behaviors. Ecotoxicol Environ Saf. 2020 Apr 15193:110367. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 485.8±55.0 °C at 760 mmHg |
| Molecular Formula | C8H7ClD3N5O3S |
| Molecular Weight | 294.733 |
| Flash Point | 247.6±31.5 °C |
| Exact Mass | 294.038116 |
| PSA | 115.02000 |
| LogP | -1.16 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.725 |
| InChIKey | NWWZPOKUUAIXIW-VZOBLPKOSA-N |
| SMILES | CN1COCN(Cc2cnc(Cl)s2)C1=N[N+](=O)[O-] |
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H410 |
| Precautionary Statements | P273-P501 |
| RIDADR | UN 3077 9 / PGIII |
Articles3
More Articles| Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014) A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ... | |
| Field-scale examination of neonicotinoid insecticide persistence in soil as a result of seed treatment use in commercial maize (corn) fields in southwestern Ontario. Environ. Toxicol. Chem. 35 , 295-302, (2016) Neonicotinoid insecticides, especially as seed treatments, have raised concerns about environmental loading and impacts on pollinators, biodiversity, and ecosystems. The authors measured concentration... | |
| Neonicotinoid insecticide residues in soil dust and associated parent soil in fields with a history of seed treatment use on crops in southwestern Ontario. Environ. Toxicol. Chem. 35 , 303-10, (2016) Using neonicotinoid insecticides as seed treatments is a common practice in field crop production. Exposure of nontarget organisms to neonicotinoids present in various environmental matrices is debate... |
Synonyms
| Thiamethoxam-d3 |
| (4Z)-3-[(2-Chloro-1,3-thiazol-5-yl)methyl]-5-(H)methyl-N-nitro-1,3,5-oxadiazinan-4-imine |
| 3-(2-Chloro-5-thiazolylmethyl)tetrahydro-5-methyl-d3-N-nitro-4H-1,3,5-oxadiazin-4-imine |
| 4H-1,3,5-Oxadiazin-4-imine, 3-[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-(methyl-d)-N-nitro-, (4Z)- |
