CAS 159857-81-5|Mc-Val-Cit-PABC-PNP

Introduction：Basic information about CAS 159857-81-5|Mc-Val-Cit-PABC-PNP, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameMc-Val-Cit-PABC-PNP
CAS Number159857-81-5Molecular Weight737.756
Density1.3±0.1 g/cm3Boiling Point1034.5±65.0 °C at 760 mmHg
Molecular FormulaC35H43N7O11Melting Point/
MSDS/Flash Point579.4±34.3 °C

Names

NameMC-Val-Cit-PABC-PNP
SynonymMore Synonyms

Mc-Val-Cit-PABC-PNP BiologicalActivity

DescriptionMc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related CatalogSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerResearch Areas >>Cancer
References

[1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders

Chemical & Physical Properties

Density1.3±0.1 g/cm3
Boiling Point1034.5±65.0 °C at 760 mmHg
Molecular FormulaC35H43N7O11
Molecular Weight737.756
Flash Point579.4±34.3 °C
Exact Mass737.302063
PSA261.15000
LogP2.71
Vapour Pressure0.0±0.3 mmHg at 25°C
Index of Refraction1.599
Storage condition2~8℃

Synonyms

maleimidocaproyl-val-Cit-PAB-OCOpNP
N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl (4-nitrophenyl)carbonate
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
maleimido-caproyl-valine-citrulline-para-aminobenzyl-4-nitrophenylcarbonate
MC-VAL-CIT-PAB-PNB
Mc-Val-Cit-PABC-PNP
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