CAS 2127-03-9|2,2′-Dipyridyl disulfide
| Common Name | 2,2′-Dipyridyl disulfide | ||
|---|---|---|---|
| CAS Number | 2127-03-9 | Molecular Weight | 220.31 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 356.1±17.0 °C at 760 mmHg |
| Molecular Formula | C10H8N2S2 | Melting Point | 56-58 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 169.2±20.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-(pyridin-2-yldisulfanyl)pyridine |
|---|---|
| Synonym | More Synonyms |
2,2′-Dipyridyl disulfide BiologicalActivity
| Description | 2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Formation of intramolecular S–S bonds can be dramatically accelerated by addition of a 2,2′-Dipyridyl disulfide (2-PDS) solution to an air-oxidized mixture of cysteine-containing peptides[1]. |
| References | [1]. K Maruyama, et al. 2,2'-Bispyridyl disulfide rapidly induces intramolecular disulfide bonds in peptides. Peptides. 1999;20(7):881-4. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 356.1±17.0 °C at 760 mmHg |
| Melting Point | 56-58 °C(lit.) |
| Molecular Formula | C10H8N2S2 |
| Molecular Weight | 220.31 |
| Flash Point | 169.2±20.9 °C |
| Exact Mass | 220.012894 |
| PSA | 76.38000 |
| LogP | 2.53 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.694 |
| InChIKey | HAXFWIACAGNFHA-UHFFFAOYSA-N |
| SMILES | c1ccc(SSc2ccccn2)nc1 |
| Storage condition | 2-8°C |
| Water Solubility | 5 g/L (20 ºC) |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R20/22;R37 |
| Safety Phrases | S36/37/39-S37/39-S25-S22 |
| RIDADR | UN3335 9 |
| WGK Germany | 3 |
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Synonyms
| di(2-pyridyl) disulfide |
| Bis(2-pyridinyl) disulfide |
| 2,2'-Dipyridyl disuldide |
| pyridyl disulfide |
| 2,2'-Dipyridyl disulfide |
| 2-Pyridinyl disulfide |
| 2,2'-DIHYDROXYDIPHENYLMETHANE |
| 2,2'-Dithiobispyridine |
| 1,2-Di(pyridin-2-yl)disulfane |
| 2-Pyridin-2-yldisulfanylpyridine |
| MFCD00006287 |
| EINECS 218-343-1 |
| 2,2‘-Dithiodipyridine |
| 2-Dipyridyl disulfide |
| Aldrithiol 2 |
| 2,2′-dipyridyldisulfide |
| bis-pyridin-2-yl-disulfide |
| pyridyldisulfide |
| 2,2'-Disulfanediyldipyridine |
| Aldrithiol |
| Bis(2-pyridyl) disulfide |
| 2,2′-dipyridyl disulfide |
| Pyridine, 2,2'-dithiobis- |
| Aldrithiol™-2 |
| 2,2'-dipyridinyl disulfide |
| 2,2'-Dithiodipyridine |
| 4,4′-dipyridyldisulfide |
