CAS 3564-73-6|10,11-Dihydrocarbamazepine
Introduction：Basic information about CAS 3564-73-6|10,11-Dihydrocarbamazepine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 10,11-Dihydrocarbamazepine | ||
|---|---|---|---|
| CAS Number | 3564-73-6 | Molecular Weight | 238.28 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 394.5±52.0 °C at 760 mmHg |
| Molecular Formula | C15H14N2O | Melting Point | 205-210ºC |
| MSDS | ChineseUSA | Flash Point | 192.4±30.7 °C |
| Symbol | GHS07, GHS08 | Signal Word | Danger |
Names
| Name | 5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide |
|---|---|
| Synonym | More Synonyms |
10,11-Dihydrocarbamazepine BiologicalActivity
| Description | 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| In Vitro | Oxcarbazepine is metabolized in the liver to its active metabolite, 10,11-Dihydrocarbamazepine. Oxcarbazepine is an antiepileptic drug (AED) used to treat partial seizures as a monotherapy or adjunctive therapy[1]. 10,11-Dihydrocarbamazepine may be used as a reference standard for the determination of 10,11-dihydrocarbamazepine in pharmaceutical formulations by liquid chromatography (LC)[1]. |
| References | [1]. Courtney Hunek, et al. Measurement of 10,11-dihydro-10-hydroxy-carbamazepine in serum and plasma by high-performance liquid chromatography. Clin Chem Lab Med. 2008;46(10):1429-33. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 394.5±52.0 °C at 760 mmHg |
| Melting Point | 205-210ºC |
| Molecular Formula | C15H14N2O |
| Molecular Weight | 238.28 |
| Flash Point | 192.4±30.7 °C |
| Exact Mass | 238.110611 |
| PSA | 46.33000 |
| LogP | 2.60 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.645 |
| InChIKey | PHNLCHMJDSSPDQ-UHFFFAOYSA-N |
| SMILES | NC(=O)N1c2ccccc2CCc2ccccc21 |
| Storage condition | Refrigerator |
| Water Solubility | dichloromethane: soluble2.5%, clear, colorless | Soluble in dichloromethane. Insoluble in water. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,88,1964
Safety Information
| Symbol | GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H317-H334 |
| Precautionary Statements | P261-P280-P342 + P311 |
| Hazard Codes | Xn |
| Risk Phrases | 22-42/43 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | HN8300000 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles6
More Articles| Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor. Eur. J. Biochem. 267(1) , 110-20, (2000) Several wasp venoms contain philanthotoxins (PhTXs), natural polyamine amides, which act as noncompetitive inhibitors (NCIs) on the nicotinic acetylcholine receptor (nAChR). Effects of varying the str... | |
| Liquid chromatographic methods for assay of carbamazepine, 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and tablets. J. Assoc. Off. Anal. Chem. 70(5) , 836-40, (1987) Liquid chromatographic (LC) methods have been developed for the determination of carbamazepine, the impurity 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and table... | |
| An orthorhombic polymorph of 10,11-dihydrocarbamazepine. Acta Crystallogr. C 62(Pt 5) , o240-2, (2006) The title compound (systematic name: 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide), C15H14N2O, is shown to crystallize as an orthorhombic polymorph to complement the known monoclinic form. The mo... |
Synonyms
| 10,11-dihydro-5-carboxamido-5H-dibenz<b,f>azepine |
| 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepin |
| 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepine |
| GP 26-301 |
| 10,11-DIHYDROCARBAMAZEPINE |
| EINECS 222-649-0 |
| 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
| 10,11-Dihydrocarbamazepine,10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
| MFCD00005072 |
| 10,11-Dihydro-5H-dibenz(b,f)azepine-5-carboxamide |
| 10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide |
| 5H-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE,10,11-DIHYDRO |
| 5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro- |
