Introduction：Basic information about CAS 51781-06-7|Carteolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Carteolol |
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| CAS Number | 51781-06-7 | Molecular Weight | 292.37300 |
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| Density | 1.13 g/cm3 | Boiling Point | 518.6ºC at 760 mmHg |
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| Molecular Formula | C16H24N2O3 | Melting Point | / |
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| MSDS | / | Flash Point | 267.4ºC |
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Names
| Name | carteolol |
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| Synonym | More Synonyms |
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Carteolol BiologicalActivity
| Description | Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>Bcl-2 FamilySignaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease |
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| In Vitro | Carteolol (0-2%; 0-28 hours; HCECs) has cytotoxicity and decreases cell viability in a dose- and time-dependent manner[1]. Carteolol (0.25%; 4-12 hours; HCECs) induces apoptosis and necroptotic protein expression in HCECs[1]. Cell Viability Assay[1] Cell Line: HCECs Concentration: 0.00390625-2% Incubation Time: 0, 2, 4, 8, 16, 20,24 and 28 hours Result: Decreased cell viability with the concentrations above 0.0015625% in a dose- and time-dependent manner. Western Blot Analysis[1] Cell Line: HCECs Concentration: 0.25% Incubation Time: 4, 8 and 12 hours Result: Dampened expression of the anti-apoptotic protein Bcl-2 and Bcl-xL, enhanced expression of the pro-apoptotic proteins Bax and Bad, and mitochondrial-released pro-apoptotic proteins Cyt.c and AIF. Cell Cycle Analysis[1] Cell Line: HCECs Concentration: 0.25% Incubation Time: 4, 8 and 12 hours Result: Increased the number of G1 phase of the cell cycle, whereas decreased S phase. |
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| References | [1]. Su W, et, al. Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms. Front Pharmacol. 2020 Mar 6;11:202. |
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Chemical & Physical Properties
| Density | 1.13 g/cm3 |
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| Boiling Point | 518.6ºC at 760 mmHg |
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| Molecular Formula | C16H24N2O3 |
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| Molecular Weight | 292.37300 |
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| Flash Point | 267.4ºC |
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| Exact Mass | 292.17900 |
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| PSA | 70.59000 |
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| LogP | 2.22800 |
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| Index of Refraction | 1.5800 (estimate) |
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| InChIKey | LWAFSWPYPHEXKX-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VC8281000
- CHEMICAL NAME :
- 2(1H)-Quinolinone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4 -dihydro-
- CAS REGISTRY NUMBER :
- 51781-06-7
- LAST UPDATED :
- 199112
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C16-H24-N2-O3
- MOLECULAR WEIGHT :
- 292.42
- WISWESSER LINE NOTATION :
- T66 BMVT&J GO1YQ1MX1&1&1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 810 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,121,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 830 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 740 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980
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Safety Information
Customs
| HS Code | 2933790090 |
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| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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Synonyms
| Carteololum |
| Carteolol [INN:BAN] |
| Carteololum [INN-Latin] |
| 5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one |
| CARTEOLOL |
| Ocupress |
| Carteolol HCl |
| Carteolol Monohydrochloride |
| Carteolol (INN) |
| 5-(3-tert-butylamino-2-hydroxy-propoxy)-3,4-dihydro-1H-quinolin-2-one |
| 5-[3-(1,1-dimethylethyl)amino-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone |
