CAS 53696-59-6|8-Azido-ATP

Introduction：Basic information about CAS 53696-59-6|8-Azido-ATP, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 8-Azido-ATP BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	8-Azido-ATP
CAS Number	53696-59-6	Molecular Weight	570.17500
Density	/	Boiling Point	/
Molecular Formula	C₁₀H₁₄N₈NaO₁₃P₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	8-azidoadenosine 5'-triphosphate, sodium salt
Synonym	More Synonyms

8-Azido-ATP BiologicalActivity

Description	8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase[1].
Related Catalog	Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel
In Vitro	8-Azido-ATP can be used to identify the viral RNA polymerase on the basis of the ability of the analog to inhibit transcription activity associated with rotavirus particles on exposure to UV light[1]. 8-Azido-ATP (azido-ATP) decreases viral transcription in a dose-dependent manner[1]. 8-Azido-ATP blocks Kir6.2ΔC26 currents rather less potently than ATP, half-maximal inhibition (Ki) occurring at 2.8 ± 0.4 mM (n = 6) compared with 172 ± 7 mM for ATP (n = 6). The Hill coefficients were 0.9 ± 0.2 for 8-azido-ATP and 1.3 ± 0.1 for ATP[2].
References	[1]. S Valenzuela, et al. Photoaffinity labeling of rotavirus VP1 with 8-azido-ATP: identification of the viral RNA polymerase. J Virol. 1991 Jul;65(7):3964-7. [2]. K Tanabe, et al. Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP. J Biol Chem. 1999 Feb 12;274(7):3931-3.

Chemical & Physical Properties

Molecular Formula	C₁₀H₁₄N₈NaO₁₃P₃
Molecular Weight	570.17500
Exact Mass	569.97900
PSA	336.11000
InChIKey	JNWKTICFNQRTBF-GWTDSMLYSA-J
SMILES	[N-]=[N+]=Nc1nc2c(N)ncnc2n1C1OC(COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])C(O)C1O.[Na+]

Safety Information

Hazard Codes	Xi

Synonyms

Adenosine 5'-(tetrahydrogen triphosphate),8-azido

8-Azido-D-adenosine5'-triphosphatesodiumsalt

8-AZIDOADENOSINE-5'-O-TRIPHOSPHATE SODIUM SALT

8-N3-ATP SODIUM SALT

Recommended......