Introduction：Basic information about CAS 55986-43-1|Cetaben, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cetaben |
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| CAS Number | 55986-43-1 | Molecular Weight | 361.561 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 503.4±33.0 °C at 760 mmHg |
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| Molecular Formula | C23H39NO2 | Melting Point | / |
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| MSDS | / | Flash Point | 258.3±25.4 °C |
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Names
| Name | 4-(hexadecylamino)benzoic acid |
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| Synonym | More Synonyms |
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Cetaben BiologicalActivity
| Description | Cetaben, an exceptional type of peroxisome proliferator, is a peroxisome proliferator-activated receptor α (PPARα)-independent peroxisome proliferator. Cetaben is a non-fibrate hypolipidemic drug and potently reduces the concentration of cholesterol and triglycerides[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
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| In Vitro | Cetaben (10 µM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 µM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles[2]. Cetaben-treated (10 µM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells[2]. |
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| In Vivo | Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg[1]. Animal Model: Male Wistar rats[1] Dosage: 10,25,50,100,250 and 500 mg/kg Administration: Gavage; 10 day Result: Revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect was observed at 250 mg/kg. |
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| References | [1]. Chandoga J, et al. Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Biochem Pharmacol. 1994 Feb 9;47(3):515-9. [2]. Kovacs W, et al. Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatomacells and HepG2 human hepatoblastoma cells. Histochem Cell Biol. 2001 Jun;115(6):509-19. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 503.4±33.0 °C at 760 mmHg |
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| Molecular Formula | C23H39NO2 |
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| Molecular Weight | 361.561 |
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| Flash Point | 258.3±25.4 °C |
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| Exact Mass | 361.298065 |
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| PSA | 49.33000 |
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| LogP | 9.68 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.521 |
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| InChIKey | QXWKHSSBFQDQPR-UHFFFAOYSA-N |
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| SMILES | CCCCCCCCCCCCCCCCNc1ccc(C(=O)O)cc1 |
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| Storage condition | -20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DH1430100
- CHEMICAL NAME :
- Benzoic acid, 4-(hexadecylamino)-
- CAS REGISTRY NUMBER :
- 55986-43-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C23-H39-N-O2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 19500 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - other changes Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 7,273,1981
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Safety Information
Customs
| HS Code | 2922499990 |
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| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 4-(Hexadecylamino)benzoic acid |
| Peroxisome Proliferator,Cetaben |
| Benzoic acid, 4-(hexadecylamino)- |
| Cetaben |
