CAS 5545-17-5|N,N'-Diacetyl-L-cystine
| Common Name | N,N'-Diacetyl-L-cystine | ||
|---|---|---|---|
| CAS Number | 5545-17-5 | Molecular Weight | 324.374 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 715.5±60.0 °C at 760 mmHg |
| Molecular Formula | C10H16N2O6S2 | Melting Point | 55-72ºC |
| MSDS | / | Flash Point | 386.5±32.9 °C |
Names
| Name | (ac-cys-oh)2 |
|---|---|
| Synonym | More Synonyms |
N,N'-Diacetyl-L-cystine BiologicalActivity
| Description | N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| Target | Immunomodulator[1] |
| In Vivo | N,N'-Diacetyl-L-cystine (DiNAC; 0-973.11 μg/kg; oral administration; daily; for 12 weeks; WHHL rabbits) treatment reduces by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels[1]. Animal Model: Male heritable hyperlipidemic rabbit (WHHL) rabbits (10-22 weeks)[1] Dosage: 0 μg/kg, 9.73 μg/kg, or 973.11 μg/kg Administration: Oral administration; daily; for 12 weeks Result: Reduced by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels. |
| References | [1]. Wågberg M, et al. N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis. J Pharmacol Exp Ther. 2001 Oct;299(1):76-82. [2]. Särnstrand B, et al. N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. J Pharmacol Exp Ther. 1999 Mar;288(3):1174-84. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 715.5±60.0 °C at 760 mmHg |
| Melting Point | 55-72ºC |
| Molecular Formula | C10H16N2O6S2 |
| Molecular Weight | 324.374 |
| Flash Point | 386.5±32.9 °C |
| Exact Mass | 324.044983 |
| PSA | 183.40000 |
| LogP | 0.46 |
| Vapour Pressure | 0.0±5.0 mmHg at 25°C |
| Index of Refraction | 1.583 |
| InChIKey | YTPQSLLEROSACP-YUMQZZPRSA-N |
| SMILES | CC(=O)NC(CSSCC(NC(C)=O)C(=O)O)C(=O)O |
| Storage condition | -15°C |
| Stability | Moisture Sensitive |
Safety Information
| HS Code | 29225090 |
|---|
Articles9
More Articles| Influence of N,N'-diacetyl-L-cystine on D-galactosamine/lipopolysaccharide induced immunological liver failure in mice. Yao Xue Xue Bao 39(10) , 782-6, (2004) To study the therapeutic effects of N,N'-diacetyl-L-cystine (DiNAC) on immunological liver failure.Serum ALT, AST and T cell subsets in peripheral blood of the experimental animals during the trial pe... | |
| Immunomodulation with DiNAC-- a new approach to the treatment of atherosclerosis? Expert Opin. Investig. Drugs 11(5) , 717-20, (2002) Not all antioxidants reduce atherosclerosis. This may be because atherosclerosis has an autoimmune, inflammatory pathogenesis. As probucol is both an antioxidant and an immunomodulatory drug, it may b... | |
| The new oral immunomodulating drug DiNAC induces brachial artery vasodilatation at rest and during hyperemia in hypercholesterolemic subjects, likely by a nitric oxide-dependent mechanism. Atherosclerosis 196(1) , 275-82, (2008) To investigate if the immunomodulator drug DINAC (1) affects arterial dimensions in asymptomatic patients with hypercholesterolemia, (2) has effects on leucocyte markers of inflammation and (3) has in... |
Synonyms
| N,N`-Diacetyl-L-cystine |
| N,N'-Diacetyl-L-cystine |
| N,N'-diacetyl-cystine |
| N-acetyl-L-cystine |
| ACETYL-L-CYSTINE |
| DiNAC |
| L-Cystine, N,N'-diacetyl- |
| Cystine, N,N'-diacetyl-, L- |
| diacetylcysteine |
| L-Cystine,N,N'-diacetyl |
| N,N''-Diacetyl-L-cysteine |
| N-ACETYL CYSTINE |
