CAS 26049-94-5|zpck
Introduction：Basic information about CAS 26049-94-5|zpck, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | zpck | ||
|---|---|---|---|
| CAS Number | 26049-94-5 | Molecular Weight | 331.793 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 503.1±50.0 °C at 760 mmHg |
| Molecular Formula | C18H18ClNO3 | Melting Point | 107-108ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | 258.1±30.1 °C |
| Symbol | GHS05 | Signal Word | Danger |
Names
| Name | benzyl N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate |
|---|---|
| Synonym | More Synonyms |
zpck BiologicalActivity
| Description | ZPCK is an oral active prodrug of gemcitabine that was designed for improved oral bioavailability[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/AnalogSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Autophagy >>Autophagy |
| References | [1]. Zhao C, et al. Pharmacokinetics and metabolism of SL-01, a prodrug of gemcitabine, in rats. Cancer Chemother Pharmacol. 2013 Jun;71(6):1541-50. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 503.1±50.0 °C at 760 mmHg |
| Melting Point | 107-108ºC(lit.) |
| Molecular Formula | C18H18ClNO3 |
| Molecular Weight | 331.793 |
| Flash Point | 258.1±30.1 °C |
| Exact Mass | 331.097534 |
| PSA | 55.40000 |
| LogP | 4.28 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.573 |
| InChIKey | OYHLRJGDELITAF-INIZCTEOSA-N |
| SMILES | O=C(NC(Cc1ccccc1)C(=O)CCl)OCc1ccccc1 |
| Storage condition | -15°C |
Safety Information
| Symbol | GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H314 |
| Precautionary Statements | P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | C |
| Risk Phrases | R34 |
| Safety Phrases | 26-27-36/37/39-45 |
| RIDADR | UN 3261 8 |
| WGK Germany | 3 |
| HS Code | 2924299090 |
Customs
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles8
More Articles| High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions. Assay Drug Dev. Technol. 12(7) , 395-418, (2014) The androgen receptor-transcriptional intermediary factor 2 (AR-TIF2) positional protein-protein interaction (PPI) biosensor assay described herein combines physiologically relevant cell-based assays ... | |
| Inhibition of carboxypeptidase Y by chloromethyl ketone derivatives of benzyloxycarbonyl-L-phenylalanine. J. Biochem. (Tokyo) 76 , 1355, (1974) | |
| A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells. Mol. Syst. Biol. 11 , 846, (2015) Small molecules often affect multiple targets, elicit off-target effects, and induce genotype-specific responses. Chemical genetics, the mapping of the genotype dependence of a small molecule's effect... |
Synonyms
| (3S)-3-benzyloxycarbonylamino-1-chloro-4-phenyl-2-butanone |
| Carbamic acid, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester |
| benzyl (S)-(1-benzyl-3-chloro-2-oxopropyl)carbamate |
| N-Carbobenzoxy-L-phenylalanyl-chloromethyl ketone |
| Lopac-C-9511 |
| N-benzyloxycarbonyl-L-phenylalanine chloromethyl ketone |
| MFCD00037114 |
| N-CBZ-L-phenylalanine chloromethyl ketone |
| Benzyl [(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate |
| ZPCK |
| N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone |
| Carbamic acid, [3-chloro-2-oxo-1- (phenylmethyl)propyl]-, phenylmethyl ester, (S)- |
| L-Carbobenzyloxyphenylalanyl chloromethyl ketone |
| Carbamic acid, [3-chloro-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester, (S)- |
| (S)-(1-benzyl-3-chloro-2-oxopropyl)carbamic acid benzyl ester |
| EINECS 247-432-8 |
| Z-L-Phe chloromethyl ketone |
| Benzyl [(2S)-4-chloro-3-oxo-1-phenyl-2-butanyl]carbamate |
| Benzyl [(1S)-1-benzyl-3-chloro-2-oxopropyl]carbamate |
| Z-Phe-CH2Cl |
| [N-(benzyloxycarbonyl)-L-phenylalanyl]methyl chloride |
| N-[(1S)-3-Chloro-2-Oxo-1-(Phenylmethyl)Propyl]-Carbamic Acid Phenylmethyl Ester |
| Z-Phe-CMK |
