CAS 51481-60-8|Naloxone hydrochloride dihydrate
Introduction：Basic information about CAS 51481-60-8|Naloxone hydrochloride dihydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Naloxone hydrochloride dihydrate | ||
|---|---|---|---|
| CAS Number | 51481-60-8 | Molecular Weight | 399.866 |
| Density | / | Boiling Point | / |
| Molecular Formula | C19H26ClNO6 | Melting Point | 182 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 288.4ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Naloxone hydrochloride dihydrate |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Melting Point | 182 °C (dec.)(lit.) |
|---|---|
| Molecular Formula | C19H26ClNO6 |
| Molecular Weight | 399.866 |
| Flash Point | 288.4ºC |
| Exact Mass | 399.144867 |
| PSA | 88.46000 |
| LogP | 1.91270 |
| InChIKey | TXMZWEASFRBVKY-IOQDSZRYSA-N |
| SMILES | C=CCN1CCC23c4c5ccc(O)c4OC2C(=O)CCC3(O)C1C5.Cl.O.O |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light. |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25-S26-S36/37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles91
More Articles| Sympathetic activity induced by naloxone-precipitated morphine withdrawal is blocked in genetically engineered mice lacking functional CRF1 receptor. Toxicol. Appl. Pharmacol. 283(1) , 42-9, (2015) There is large body evidence indicating that stress can lead to cardiovascular disease. However, the exact brain areas and the mechanisms involved remain to be revealed. Here, we performed a series of... | |
| Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy. Life Sci. 92(23) , 1138-44, (2013) In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between ... | |
| Effects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis. PLoS ONE 10 , e0125147, (2015) Tramadol is thought to modulate synaptic transmissions in the spinal dorsal horn mainly by activating µ-opioid receptors and by inhibiting the reuptake of monoamines in the CNS. However, the precise m... |
Synonyms
| (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one,dihydrate,hydrochloride |
| (5α)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride dihydrate |
| Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5α)-, hydrochloride, hydrate (1:1:2) |
| EINECS 206-611-0 |
| MFCD00150901 |
| Naloxone HCl Dihydrate |
| Naloxone hydrochloride dihydrate |
