Introduction：Basic information about CAS 14882-18-9|Bismuth Subsalicylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bismuth Subsalicylate |
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| CAS Number | 14882-18-9 | Molecular Weight | 362.093 |
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| Density | / | Boiling Point | 336.3ºC at 760mmHg |
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| Molecular Formula | C7H5BiO4 | Melting Point | >35ºC |
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| MSDS | / | Flash Point | 144.5ºC |
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Names
| Name | bismuth subsalicylate |
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| Synonym | More Synonyms |
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Bismuth Subsalicylate BiologicalActivity
| Description | Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.Target: OthersBismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H Synthase 1/2 [1]. Bismuth Subsalicylate is the active ingredient in Pepto-Bismol, an anti-diarrhea medication and antacid. In the gastrointestinal tract, Bismuth Subsalicylate is converted to salicylic acid and insoluble bismuth salts [2]. Bismuth subsalicylate treatment for 8 weeks is safe and well tolerated. This regimen appears to be efficacious for the treatment of microscopic colitis and is worthy of further study in a controlled trial [3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>PGE synthaseResearch Areas >>Neurological Disease |
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| References | [1]. Sox, T.E. and C.A. Olson, Binding and killing of bacteria by bismuth subsalicylate. Antimicrob Agents Chemother, 1989. 33(12): p. 2075-82. [2]. Bierer, D.W., Bismuth subsalicylate: history, chemistry, and safety. Rev Infect Dis, 1990. 12 Suppl 1: p. S3-8. [3]. Fine, K.D. and E.L. Lee, Efficacy of open-label bismuth subsalicylate for the treatment of microscopic colitis. Gastroenterology, 1998. 114(1): p. 29-36. |
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Chemical & Physical Properties
| Boiling Point | 336.3ºC at 760mmHg |
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| Melting Point | >35ºC |
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| Molecular Formula | C7H5BiO4 |
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| Molecular Weight | 362.093 |
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| Flash Point | 144.5ºC |
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| Exact Mass | 361.999176 |
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| PSA | 55.76000 |
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| LogP | 0.97400 |
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| Vapour Pressure | 4.45E-05mmHg at 25°C |
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| InChIKey | QBWLKDFBINPHFT-UHFFFAOYSA-L |
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| SMILES | O.O=C1O[Bi]Oc2ccccc21 |
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| Water Solubility | Practically insoluble in water, alcoholSoluble in acid and alkali. Insoluble in cold water, ethanol, diethyl ether and n-octanol. |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- EB2985000
- CHEMICAL NAME :
- Bismuth, oxo(salicylato)-
- CAS REGISTRY NUMBER :
- 14882-18-9
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C7-H5-Bi-O4
- MOLECULAR WEIGHT :
- 362.10
- WISWESSER LINE NOTATION :
- QR BVO-BI-O
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 60 mg/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- REFERENCE :
- AJCPAI American Journal of Clinical Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1931- Volume(issue)/page/year: 14,392,1944
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 14480 ug/kg/9D-I
- TOXIC EFFECTS :
- Musculoskeletal - joints Skin and Appendages - dermatitis, allergic (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- ADSYAF Archives of Dermatology and Syphilology. (Chicago, IL) V.1-62, 1920-50. For publisher information, see ARDEAC. Volume(issue)/page/year: 41,1076,1940
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 17 mg/kg/5W-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes
- REFERENCE :
- AJSGA3 American Journal of Syphilis, Gonorrhea and Venereal Diseases. (St. Louis, MO) V.20-38, 1936-54. Discontinued. Volume(issue)/page/year: 26,84,1942 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80378 No. of Facilities: 96 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 3666 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80378 No. of Facilities: 405 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 4036 (estimated) No. of Female Employees: 2022 (estimated)
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | EB2985000 |
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Synonyms
| Bismuth(III) salicylate basic |
| Bismuth oxide salicylate |
| Bismuth Subsalicylate |
| 4H-1,3,2-Benzodioxabismin-4-one, 2-hydroxy- |
| EINECS 238-953-1 |
| MFCD00085368 |
| Bismuth(III) subsalicylate |
| Bismuth, (2-hydroxybenzoato-O1,O2)oxo- |
| 2-Hydroxy-4H-1,3,2-benzodioxabismin-4-one |
| Bismuth oxysalicylate |
| Pepto-Bismol |
