CAS 21343-40-8|25-Hydroxycalciferol
| Common Name | 25-Hydroxycalciferol | ||
|---|---|---|---|
| CAS Number | 21343-40-8 | Molecular Weight | 412.648 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 542.3±38.0 °C at 760 mmHg |
| Molecular Formula | C28H44O2 | Melting Point | 45-51ºC |
| MSDS | ChineseUSA | Flash Point | 225.9±21.4 °C |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | 25-hydroxyvitamin D2 |
|---|---|
| Synonym | More Synonyms |
25-Hydroxycalciferol BiologicalActivity
| Description | Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status. |
|---|---|
| Related Catalog | Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Metabolic DiseaseNatural Products >>Steroids |
| Target | Human Endogenous Metabolite |
| In Vitro | Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2[2]. |
| References | [1]. Li L, et al. Performance evaluation of two immunoassays for 25-hydroxyvitamin D. J Clin Biochem Nutr. 2016 May;58(3):186-92. [2]. Newman MS, et al. A liquid chromatography/tandem mass spectrometry method for determination of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in dried blood spots: a potential adjunct to diabetes and cardiometabolic risk screening. J Diabetes Sci Technol |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 542.3±38.0 °C at 760 mmHg |
| Melting Point | 45-51ºC |
| Molecular Formula | C28H44O2 |
| Molecular Weight | 412.648 |
| Flash Point | 225.9±21.4 °C |
| Exact Mass | 412.334137 |
| PSA | 40.46000 |
| LogP | 7.56 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.543 |
| InChIKey | KJKIIUAXZGLUND-CDHMVDRZSA-N |
| SMILES | C=C1CCC(O)CC1=CC=C1CCCC2(C)C1CCC2C(C)C=CC(C)C(C)(C)O |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H319 |
| Precautionary Statements | P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+,F |
| Risk Phrases | 24/25-26-48/25-11 |
| Safety Phrases | 28-36/37-45-16-7 |
| RIDADR | UN2811 6 |
Articles47
More Articles| Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research. Biomed. Chromatogr. 28(6) , 913-7, (2014) The accurate and specific measurement of vitamin D is increasingly important for determining the role of vitamin D in the pathogenesis of disease. Liquid chromatography coupled to tandem mass spectrom... | |
| Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D₃-fortified bread and milk during winter in Denmark. Am. J. Clin. Nutr. 101(1) , 218-27, (2015) Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet (UV)B-induced 25-hydroxyvitamin D [25(OH)D] concentrations. In the Food with vitamin D (VitmaD) stu... | |
| Prospective association of 25-hydroxyvitamin d3 and d2 with childhood lung function, asthma, wheezing, and flexural dermatitis. Epidemiology 24(2) , 310-9, (2013) Higher serum total 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with better lung function and lower risk of allergic disease. 25(OH)D3 constitutes the majority of total 25(OH)D an... |
Synonyms
| 25-Hydroxy Vitamin D2 |
| (3S,5Z,7E,20R,22E)-9,10-Secoergosta-5,7,10,22-tetraene-3,25-diol |
| 9,10-Secoergosta-5,7,10(19),22-tetraene-3b,25-diol |
| 9,10-Secoergosta-5,7,10(19),22-tetraene-3β,25-diol |
| Ercalcidiol,3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3,25-diol |
| EINECS 200-578-6 |
| 25-Hydroxyvitamin D2 |
| 25-Hydroxyvitamin D 2 |
| 25-Hydroxyergocalciferol |
| 25-Hydroxyergocalciferol 25-Hydroxycalciferol |
| Cyclohexanol, 4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1S,3Z)- |
| 9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol, (3β,5Z,7E,22E)- |
| MFCD02683431 |
| 25-Hydroxycalciferol |
| Ercalcidiol |
