Introduction：Basic information about CAS 264622-58-4|MRS 1754, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MRS 1754 |
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| CAS Number | 264622-58-4 | Molecular Weight | 486.52200 |
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| Density | 1.38g/cm3 | Boiling Point | / |
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| Molecular Formula | C26H26N6O4 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide |
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| Synonym | More Synonyms |
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MRS 1754 BiologicalActivity
| Description | MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Adenosine Receptor |
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| Target | A2B Adenosine Receptor[1] |
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| In Vitro | The most potent displacer of [3H]MRS 1754 binding is MRS 1754. The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM[1]. |
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| References | [1]. Ji X, et al. [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochem Pharmacol. 2001 Mar 15;61(6):657-63. |
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Chemical & Physical Properties
| Density | 1.38g/cm3 |
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| Molecular Formula | C26H26N6O4 |
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| Molecular Weight | 486.52200 |
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| Exact Mass | 486.20200 |
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| PSA | 134.80000 |
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| LogP | 3.33548 |
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| InChIKey | AJBBEYXFRYFVNM-UHFFFAOYSA-N |
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| SMILES | CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)nc2n(CCC)c1=O |
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| Storage condition | 2-8℃ |
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Safety Information
Synonyms
| MRS 1754 hydrate |
| MRS 1754 |
| ML 9 hydrochloride |
| Lopac-M-6316 |
