Introduction：Basic information about CAS 38183-03-8|7,8-Dihydroxyflavone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 7,8-Dihydroxyflavone |
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| CAS Number | 38183-03-8 | Molecular Weight | 254.24 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 494.4±45.0 °C at 760 mmHg |
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| Molecular Formula | C15H10O4 | Melting Point | 243-246°C |
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| MSDS | ChineseUSA | Flash Point | 193.5±22.2 °C |
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Names
| Name | 7,8-dihydroxyflavone |
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| Synonym | More Synonyms |
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7,8-Dihydroxyflavone BiologicalActivity
| Description | 7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1]. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Trk ReceptorResearch Areas >>Neurological Disease |
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| Target | TrkB[1] |
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| In Vitro | 7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1]. |
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| In Vivo | 7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2]. |
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| References | [1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 494.4±45.0 °C at 760 mmHg |
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| Melting Point | 243-246°C |
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| Molecular Formula | C15H10O4 |
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| Molecular Weight | 254.24 |
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| Flash Point | 193.5±22.2 °C |
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| Exact Mass | 254.057907 |
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| PSA | 70.67000 |
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| LogP | 2.51 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.699 |
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| InChIKey | COCYGNDCWFKTMF-UHFFFAOYSA-N |
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| SMILES | O=c1cc(-c2ccccc2)oc2c(O)c(O)ccc12 |
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| Storage condition | Store at +4°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DJ3004000
- CHEMICAL NAME :
- 4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl-
- CAS REGISTRY NUMBER :
- 38183-03-8
- BEILSTEIN REFERENCE NO. :
- 0234350
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C15-H10-O4
- MOLECULAR WEIGHT :
- 254.25
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Human HeLa cell
- DOSE/DURATION :
- 12500 ug/L
- REFERENCE :
- PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 27,1017,1988
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 22 |
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| Safety Phrases | S24/25 |
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| RTECS | DJ3004000 |
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| HS Code | 2914400090 |
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Customs
| HS Code | 2914400090 |
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| Summary | 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 7,8-dihydroxy-2-phenylchromen-4-one |
| 7,8-Dihydroxyflavone Hydrate |
| 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one |
| EINECS 253-812-4 |
| 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one |
| MFCD00006836 |
| 7,8-Dihydroxyflavone |
| 4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl- |
