Introduction：Basic information about CAS 402713-80-8|SB-399885, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SB-399885 |
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| CAS Number | 402713-80-8 | Molecular Weight | 446.34800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C18H21Cl2N3O4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide,hydrochloride |
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| Synonym | More Synonyms |
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SB-399885 BiologicalActivity
| Description | SB399885 is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with pKi values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties[1]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT6 Receptor:9.02 (pKi) Human 5-HT6 Receptor:9.11 (pKi) |
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| References | [1]. Warren D Hirst, et al. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19. |
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Chemical & Physical Properties
| Molecular Formula | C18H21Cl2N3O4S |
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| Molecular Weight | 446.34800 |
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| Exact Mass | 445.06300 |
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| PSA | 88.28000 |
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| LogP | 4.76860 |
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| InChIKey | ATKZKAYWARYLBW-UHFFFAOYSA-N |
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| SMILES | COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2OC)cc1N1CCNCC1 |
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Synonyms
| N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(piperazin-1-yl)benzenesulfonamide |
| N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide |
| Benzenesulfonamide, N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)- |
