CAS 148396-36-5|Fradafiban

Introduction：Basic information about CAS 148396-36-5|Fradafiban, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Fradafiban BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Fradafiban
CAS Number	148396-36-5	Molecular Weight	367.39800
Density	1.38g/cm3	Boiling Point	/
Molecular Formula	C₂₀H₂₁N₃O₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	2-[(3S,5S)-5-[[4-(4-carbamimidoylphenyl)phenoxy]methyl]-2-oxopyrrolidin-3-yl]acetic acid
Synonym	More Synonyms

Fradafiban BiologicalActivity

Description	Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.
Related Catalog	Signaling Pathways >>Cytoskeleton >>IntegrinResearch Areas >>Cardiovascular Disease
Target	Kd: 148 nM (human platelet GP IIb/IIIa complex)[1]
In Vitro	Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM[1].
In Vivo	Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion[1].
References	[1]. Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8.

Chemical & Physical Properties

Density	1.38g/cm3
Molecular Formula	C₂₀H₂₁N₃O₄
Molecular Weight	367.39800
Exact Mass	367.15300
PSA	125.50000
LogP	3.12470
Index of Refraction	1.659
InChIKey	IKZACQMAVUIGPY-HOTGVXAUSA-N
SMILES	N=C(N)c1ccc(-c2ccc(OCC3CC(CC(=O)O)C(=O)N3)cc2)cc1
Storage condition	2-8℃

Synonyms

UNII-DQ0H2B8YKN

C20H21N3O4

fradafibanum

Fradafiban

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