CAS 90614-48-5|Diprotin A
Introduction：Basic information about CAS 90614-48-5|Diprotin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Diprotin A | ||
|---|---|---|---|
| CAS Number | 90614-48-5 | Molecular Weight | 341.44600 |
| Density | 1.14 g/cm3 | Boiling Point | 583.1ºC at 760 mmHg |
| Molecular Formula | C17H31N3O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 306.5ºC |
Names
| Name | diprotin a |
|---|---|
| Synonym | More Synonyms |
Diprotin A BiologicalActivity
| Description | Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Dipeptidyl PeptidaseResearch Areas >>Metabolic Disease |
| Target | IC50: DPP-IV[1] |
| In Vitro | Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1]. Western Blot Analysis[1] Cell Line: Human endothelial cells[1] Concentration: 100 μM Incubation Time: 30 minutes after CXCR4-blocker or Src-inhibitor treatment Result: Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs. |
| In Vivo | Diprotin A (intraperitoneal injection; 70 μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1]. Animal Model: Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice[1] Dosage: 70 μg/kg Administration: Intraperitoneal injection; twice daily; 7 days Result: Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway. |
| References | [1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393. |
Chemical & Physical Properties
| Density | 1.14 g/cm3 |
|---|---|
| Boiling Point | 583.1ºC at 760 mmHg |
| Molecular Formula | C17H31N3O4 |
| Molecular Weight | 341.44600 |
| Flash Point | 306.5ºC |
| Exact Mass | 341.23100 |
| PSA | 112.73000 |
| LogP | 1.99540 |
| Index of Refraction | 1.517 |
| InChIKey | JNTMAZFVYNDPLB-PEDHHIEDSA-N |
| SMILES | CCC(C)C(N)C(=O)N1CCCC1C(=O)NC(C(=O)O)C(C)CC |
| Storage condition | −20°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,422,1984
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NR4737000 |
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Synonyms
| MFCD00038707 |
| H-ILE-PRO-ILE-OH |
| ILE-PRO-ILE H2O |
| Ile-Pro-Ile-OH |
| H-ILE-PRO-ILE-OH H2O |
| DIPEPTIDYLPEPTIDASE IV INHIBITOR I |
| L-Isoleucyl-L-prolyl-L-isoleucine |
| ILE-PRO-ILE |
| L-Ile-L-Pro-L-Ile-OH |
