Introduction：Basic information about CAS 80651-76-9|Sanggenon C, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sanggenon C |
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| CAS Number | 80651-76-9 | Molecular Weight | 708.707 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 999.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C40H36O12 | Melting Point | / |
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| MSDS | / | Flash Point | 312.7±27.8 °C |
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Names
| Name | 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-enyl)-[1]benzofuro[3,2-b]chromen-11-one |
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| Synonym | More Synonyms |
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Sanggenon C BiologicalActivity
| Description | Sanggenon C is a flavanone Diels-Alder adduct compound, which is isolated from the root bark of Morus cathayana. Sanggenon C exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, by suppressing NF-κB activity[1]. Sanggenon C possesses antioxidant, anti-inflammatory activities and inhibits Pancreatic lipase (PL) with the an IC50 of 3.00 μM[2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseResearch Areas >>Inflammation/Immunology |
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| Target | NF-κB |
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| References | [1]. Xiao L, et al. Sanggenon C protects against pressure overload induced cardiac hypertrophy via the calcineurin/NFAT2 pathway. Mol Med Rep. 2017 Oct;16(4):5338-5346. [2]. Hou XD , et al. Natural constituents from Cortex Mori Radicis as new pancreatic lipase inhibitors. Bioorg Chem. 2018 Oct;80:577-584. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 999.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C40H36O12 |
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| Molecular Weight | 708.707 |
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| Flash Point | 312.7±27.8 °C |
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| Exact Mass | 708.220703 |
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| PSA | 214.44000 |
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| LogP | 7.94 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.727 |
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| InChIKey | XETHJOZXBVWLLM-QAHMVTMMSA-N |
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| SMILES | CC(C)=CCC12Oc3cc(O)c(C4C=C(C)CC(c5ccc(O)cc5O)C4C(=O)c4ccc(O)cc4O)c(O)c3C(=O)C1(O)Oc1cc(O)ccc12 |
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| Storage condition | 2-8℃ |
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Synonyms
| 2-[(1S,5S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-5a,10a-dihydro-11H-[1]benzofuro[3,2-b]chromen-11-one |
| sanggenon D |
| Sanggenon C |
| 2-[(1S,5S,6R)-6-(2,4-Dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-1,3,5a,8-tetrahydroxy-10a-(3-methyl-2-buten-1-yl)-5a,10a-dihydro-11H-[1]benzofuro[3,2-b]chromen-11-one |
| 11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,5a,8-tetrahydroxy-10a-(3-methyl-2-buten-1-yl)- |
| 11H-Benzofuro[3,2-b][1]benzopyran-11-one, 2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)- |
| sanggennon D |
| Sanggenone C |
| sanggenone D |
