Introduction：Basic information about CAS 51020-86-1|Licarin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Licarin A |
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| CAS Number | 51020-86-1 | Molecular Weight | 326.386 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 452.0±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H22O4 | Melting Point | / |
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| MSDS | / | Flash Point | 227.2±28.7 °C |
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Names
| Name | Licarin A |
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| Synonym | More Synonyms |
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Licarin A BiologicalActivity
| Description | Licarin A ((+)-Licarin A), a neolignan isolated from various plants, significantly and dose-dependently reduces TNF-α production (IC50=12.6±0.3 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression[1]。 |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COXResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological Disease |
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| In Vitro | Licarin A is found in plants such as Aristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects[1]. Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels[1]. |
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| References | [1]. Takuya Matsui, et al. Licarin A Is a Candidate Compound for the Treatment of Immediate Hypersensitivity via Inhibition of Rat Mast Cell Line RBL-2H3 Cells. J Pharm Pharmacol. 2015 Dec;67(12):1723-32. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 452.0±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H22O4 |
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| Molecular Weight | 326.386 |
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| Flash Point | 227.2±28.7 °C |
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| Exact Mass | 326.151794 |
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| PSA | 47.92000 |
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| LogP | 4.19 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.596 |
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| InChIKey | ITDOFWOJEDZPCF-WSQXBVHWSA-N |
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| SMILES | CC=Cc1cc(OC)c2c(c1)C(C)C(c1ccc(O)c(OC)c1)O2 |
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Safety Information
Synonyms
| 2-Methoxy-4-{(2S,3S)-7-methoxy-3-methyl-5-[(1E)-1-propen-1-yl]-2,3-dihydro-1-benzofuran-2-yl}phenol |
| Phenol, 4-[(2S,3S)-2,3-dihydro-7-methoxy-3-methyl-5-[(1E)-1-propen-1-yl]-2-benzofuranyl]-2-methoxy- |
| Licarin A |
| dehydrodiisoeugenol |
