CAS 67953-08-6|GPNA hydrochloride
| Common Name | GPNA hydrochloride | ||
|---|---|---|---|
| CAS Number | 67953-08-6 | Molecular Weight | 303.69900 |
| Density | / | Boiling Point | 590.6ºC at 760 mmHg |
| Molecular Formula | C11H14ClN3O5 | Melting Point | / |
| MSDS | USA | Flash Point | 311ºC |
Names
| Name | L-Glutamic acid γ-(p-nitroanilide) hydrochloride |
|---|---|
| Synonym | More Synonyms |
GPNA hydrochloride BiologicalActivity
| Description | GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
| Target | ASCT2[1] |
| In Vitro | GPNA (10-1000 μM; 48 hours) induces a dose-dependent decrease of cell viability in A549 cells[1]. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 10, 100, 250, 500 , and 1000 μM Incubation Time: 48 hours Result: Induced a dose-dependent decrease of cell viability, with an IC50 roughly corresponding to ~250 μM. |
| References | [1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891. |
Chemical & Physical Properties
| Boiling Point | 590.6ºC at 760 mmHg |
|---|---|
| Molecular Formula | C11H14ClN3O5 |
| Molecular Weight | 303.69900 |
| Flash Point | 311ºC |
| Exact Mass | 303.06200 |
| PSA | 138.24000 |
| LogP | 2.82390 |
| InChIKey | OJEVFSFTVARWQX-FVGYRXGTSA-N |
| SMILES | Cl.NC(CCC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
Articles26
More Articles| Donor substrate specificity of bovine kidney gamma-glutamyltransferase Chem. Biol. Interact. 203(2) , 480-5, (2013) Highlights • Five aromatic or polycyclic aromatic glutathione conjugates were synthesized. • Enzyme kinetic studies were performed for each conjugate as a γ-glutamyltransferase (GGT) donor substrate. ... | |
| Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells. J. Steroid Biochem. Mol. Biol. 149 , 118-27, (2015) Resistance to endocrine therapies in hormone receptor (HR)-positive breast cancer is a significant clinical problem for a considerable number of patients. The oncogenic transcription factor c-MYC (her... | |
| Rapid purification and characterization of γ-glutamyl-transpeptidase from shiitake mushroom (Lentinus edodes). J. Food Sci. 77(6) , C640-5, (2012) γ-Glutamyl-transpeptidase (GGT) is one of the important enzymes in the pathway of odor formation in shiitake mushroom (Lentinus edodes). Rapid purification and characterization of GGT from shiitake mu... |
Synonyms
| L-GLUTAMIC ACID γ-(P-NITROANILIDE) HYDROCHLORIDE |
