Introduction：Basic information about CAS 1131-64-2|3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXIMIDAMIDE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXIMIDAMIDE |
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| CAS Number | 1131-64-2 | Molecular Weight | 175.23 |
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| Density | 1.24g/cm3 | Boiling Point | 309.8ºC at 760mmHg |
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| Molecular Formula | C10H13N3 | Melting Point | / |
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| MSDS | / | Flash Point | 141.1ºC |
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Names
| Name | debrisoquin |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>SARS-CoV |
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| Target | Human Endogenous Metabolite |
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| References | [1]. Amanda L. Peiffer, et.al.TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform.ACS Medicinal Chemistry Letters 2023 14 (6), 860-866. |
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Chemical & Physical Properties
| Density | 1.24g/cm3 |
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| Boiling Point | 309.8ºC at 760mmHg |
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| Molecular Formula | C10H13N3 |
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| Molecular Weight | 175.23 |
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| Flash Point | 141.1ºC |
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| Exact Mass | 175.11100 |
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| PSA | 53.11000 |
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| LogP | 1.67610 |
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| Vapour Pressure | 0.000626mmHg at 25°C |
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| Index of Refraction | 1.649 |
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| InChIKey | JWPGJSVJDAJRLW-UHFFFAOYSA-N |
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| SMILES | N=C(N)N1CCc2ccccc2C1 |
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Safety Information
Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 3,4-Dihydroisoquinoline-2(1H)-carboxiMidaMide |
| EINECS 214-470-1 |
| 3,4-Dihydro-2(1H)-isochinolin-carboxamidin |
| 3,4-dihydro-1H-isoquinoline-2-carboximidic acid amide |
| 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide |
| Debrisoquin |
| Debrisochin |
| 1,2,3,4-Tetrahydroisochinolin-N-carboxamidin |
| 3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXAMIDINE |
| Isocaramidine |
| 3,4-Dihydro-2(1H)-isoquinolinecarbimidamide |
| 3,4-dihydro-1H-isoquinoline-2-carboximidamide |
