CAS 30236-32-9|(+)-Sotalol
| Common Name | (+)-Sotalol | ||
|---|---|---|---|
| CAS Number | 30236-32-9 | Molecular Weight | 272.36400 |
| Density | 1.239g/cm3 | Boiling Point | 443.3ºC at 760mmHg |
| Molecular Formula | C12H20N2O3S | Melting Point | / |
| MSDS | / | Flash Point | 221.9ºC |
Names
| Name | (+)-(s)-n-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide |
|---|---|
| Synonym | More Synonyms |
(+)-Sotalol BiologicalActivity
| Description | (+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease |
| Target | β-adrenoceptor |
| In Vitro | (+)-Sotalol (1, 10, 100 µM) 在离体心肌中增加动作电位持续时间[2]。 (+)-Sotalol (100 μM，60 分钟) 可延长三种细胞类型 (心内膜、心外膜、心肌中部和透壁细胞) 的动作电位[4]。 |
| In Vivo | (+)-Sotalol (8 mg/kg，静脉注射) 抑制程序刺激诱导的犬室性心动过速[3]。 Animal Model: Programmed stimulated Dogs[3] Dosage: 8 mg/kg Administration: Intravenous injection (i.v.) Result: Increased normal zone ventricular refractoriness, and prevented propagation of programmed ventricular extra-stimuli of sufficient prematurity to elicit tachyarrhythmias. |
| References | [1]. ChuanjunLu, et al. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol. Tetrahedron: Asymmetry.Volume 22, Issue 7.11 April 2011, Pages 722-727 [2]. Kato R, et al. Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics. J Am Coll Cardiol. 1986 Jan;7(1):116-25. [3]. Lynch JJ, et al. Antiarrhythmic and antifibrillatory actions of the levo- and dextrorotatory isomers of sotalol. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1132-41. [4]. Serge Sicouri, et al. d-Sotalol Induces Marked Action Potential Prolongation and Early Afterdepolarizations in M but Not Epicardial or Endocardial Cells of the Canine Ventricle. Journal of Cardiovascular Pharmacology and Therapeuticshttps. 2016. |
Chemical & Physical Properties
| Density | 1.239g/cm3 |
|---|---|
| Boiling Point | 443.3ºC at 760mmHg |
| Molecular Formula | C12H20N2O3S |
| Molecular Weight | 272.36400 |
| Flash Point | 221.9ºC |
| Exact Mass | 272.11900 |
| PSA | 86.81000 |
| LogP | 2.63420 |
| Index of Refraction | 1.57 |
| InChIKey | ZBMZVLHSJCTVON-GFCCVEGCSA-N |
| SMILES | CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1 |
Synonyms
| Sotolol |
| Betacotdone |
| d,l-sotalol |
| SORBITOL |
