CAS 129724-84-1|Anemoside A3

Introduction：Basic information about CAS 129724-84-1|Anemoside A3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Anemoside A3 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Anemoside A3
CAS Number	129724-84-1	Molecular Weight	750.956
Density	1.31	Boiling Point	846.3±65.0 °C at 760 mmHg
Molecular Formula	C₄₁H₆₆O₁₂	Melting Point	/
MSDS	/	Flash Point	249.6±27.8 °C

Names

Name	(3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]ox y}-23-hydroxylup-20(29)-en-28-oic acid
Synonym	More Synonyms

Anemoside A3 BiologicalActivity

Description	Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.In vitro: Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10 μg/ml, protected PC12 cells from apoptosis. [1]In vivo:AA3 also acts as a non-competitive NMDA receptor (NMDAR) modulator with a neuroprotective capacity against ischemic brain injury and overexcitation in rats. [2] Anemoside A3 produces relaxation in rat renal arteries through multiple mechanisms. [3]
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides
References	[1]. Ip FC et al. Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection. Neuropsychopharmacology. 2015 Jul;40(8):1877-87. [2]. Zhang DM et al. Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition. Planta Med. 2010 Nov;76(16):1814-9. [3]. Gao XD et al. Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation. Planta Med. 2003 Feb;69(2):171-4.

Description

Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.In vitro: Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10 μg/ml, protected PC12 cells from apoptosis. [1]In vivo:AA3 also acts as a non-competitive NMDA receptor (NMDAR) modulator with a neuroprotective capacity against ischemic brain injury and overexcitation in rats. [2] Anemoside A3 produces relaxation in rat renal arteries through multiple mechanisms. [3]

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides

References

[1]. Ip FC et al. Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection. Neuropsychopharmacology. 2015 Jul;40(8):1877-87.

[2]. Zhang DM et al. Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition. Planta Med. 2010 Nov;76(16):1814-9.

[3]. Gao XD et al. Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation. Planta Med. 2003 Feb;69(2):171-4.

Chemical & Physical Properties

Density	1.31
Boiling Point	846.3±65.0 °C at 760 mmHg
Molecular Formula	C₄₁H₆₆O₁₂
Molecular Weight	750.956
Flash Point	249.6±27.8 °C
Exact Mass	750.455444
PSA	195.60000
LogP	8.26
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.597
InChIKey	ISNDTNDJSXYNKT-DVIRKNLQSA-N
SMILES	C=C(C)C1CCC2(C(=O)O)CCC3(C)C(CCC4C5(C)CCC(OC6OCC(O)C(O)C6OC6OC(C)C(O)C(O)C6O)C(C)(CO)C5CCC43C)C12
Storage condition	-20°C

Synonyms

Pulchinenoside A

Lup-20(29)-en-28-oic acid, 3-[[2-O-(6-deoxy-α-D-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β)-

Lup-20(29)-en-28-oic acid, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β)-

Anemoside A3

(3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxylup-20(29)-en-28-oic acid

(3β)-3-{[2-O-(6-Deoxy-α-D-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxylup-20(29)-en-28-oic acid

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