Introduction：Basic information about CAS 14965-20-9|Chrysosplenol D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chrysosplenol D |
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| CAS Number | 14965-20-9 | Molecular Weight | 360.315 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 645.0±55.0 °C at 760 mmHg |
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| Molecular Formula | C18H16O8 | Melting Point | / |
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| MSDS | / | Flash Point | 237.3±25.0 °C |
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Names
| Name | 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one |
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| Synonym | More Synonyms |
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Chrysosplenol D BiologicalActivity
| Description | Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>InfectionResearch Areas >>Inflammation/Immunology |
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| In Vitro | Chrysosplenol D inhibits the cell viability of CaCo2 cells, with IC50 of 63.48 μM[1]. Chrysosplenol D (1-100 μM; 48 h) selectively inhibits the viability of the TNBC cell lines, MDA-MB-231, CAL-51, CAL-148, as well as MCF7, A549, MIA PaCa-2, and PC-3[2]. Chrysosplenol D (1-10 μM; 48 h) induces cell cycle aberrations with accumulation of cells in the S-phase and partially in the G2/M-phase of the cell cycle[2]. Chrysosplenol D (1-10 μM; 48 h) induce apoptosis in breast cancer cells[2]. Chrysosplenol D shows moderate antitrypanosomal activity, with IC50 of 47.27 μM for T.b. brucei[3]. |
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| In Vivo | Chrysosplenol D (30 μM; 3 d) inhibits MDA-MB-231 tumor growth on chick chorioallantoic membranes[2]. Chrysosplenol D (0.07-0.28 mmol/kg) protects against LPS-induced systemic inflammatory response syndrome (SIRS) in mice[4]. Chrysosplenol D (1-1.5 μmol/cm2) inhibits croton oil-induced ear edema in mice[4]. |
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| References | [1]. Habib ES, et, al. Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus (Jasonia Montana) growing in Egypt. Nat Prod Res. 2020 Aug 4;1-5. [2]. Lang SJ, et, al. Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells. Int J Mol Sci. 2020 Jun 8;21(11):4090. [3]. Skaf J, et, al. Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima. Fitoterapia. 2018 Mar;125:191-198. [4]. Li YJ, et, al. Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):151-8. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 645.0±55.0 °C at 760 mmHg |
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| Molecular Formula | C18H16O8 |
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| Molecular Weight | 360.315 |
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| Flash Point | 237.3±25.0 °C |
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| Exact Mass | 360.084503 |
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| PSA | 118.59000 |
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| LogP | 2.29 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.680 |
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| InChIKey | BYWLLSQTJBXAPV-UHFFFAOYSA-N |
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| SMILES | COc1cc2oc(-c3ccc(O)c(O)c3)c(OC)c(=O)c2c(O)c1OC |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone |
| 3',4',5-Trihydroxy-3,6,7-trimethoxyflavone |
| quercetagetin 3,6,7-trimethylether |
| 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy- |
| 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one |
| Chrysosplenol D |
| chrysophenol-D |
