CAS 152302-45-9|7-Desmethylagomelatine

Introduction：Basic information about CAS 152302-45-9|7-Desmethylagomelatine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 7-Desmethylagomelatine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	7-Desmethylagomelatine
CAS Number	152302-45-9	Molecular Weight	229.274
Density	1.2±0.1 g/cm3	Boiling Point	511.3±33.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₅NO₂	Melting Point	/
MSDS	/	Flash Point	263.0±25.4 °C

Names

Name	N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide
Synonym	More Synonyms

7-Desmethylagomelatine BiologicalActivity

Description	7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306(3):954-64. [2]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6.

Description

7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306(3):954-64.

[2]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	511.3±33.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₅NO₂
Molecular Weight	229.274
Flash Point	263.0±25.4 °C
Exact Mass	229.110275
PSA	52.82000
LogP	1.62
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.624
InChIKey	UNTZQBYXDYYXIY-UHFFFAOYSA-N
SMILES	CC(=O)NCCc1cccc2ccc(O)cc12

Safety Information

HS Code	2924299090

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

Acetamide, N-[2-(7-hydroxy-1-naphthalenyl)ethyl]-

7-Demethyl-Agomelatine

N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide

N-[2-(7-Hydroxy-1-naphthyl)ethyl]acetamide

N-(2-(7-hydroxy-1-naphthyl)ethyl)acetamide

Agomelatine Impurity 12

7-Desmethylagomelatine

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