Introduction：Basic information about CAS 53174-06-4|(S)-Trolox, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (S)-Trolox |
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| CAS Number | 53174-06-4 | Molecular Weight | 250.29000 |
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| Density | 1.219g/cm3 | Boiling Point | 450.3ºC at 760 mmHg |
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| Molecular Formula | C14H18O4 | Melting Point | 160ºC (dec.)(lit.) |
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| MSDS | ChineseUSA | Flash Point | 171ºC |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | (2S)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid |
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| Synonym | More Synonyms |
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(S)-Trolox BiologicalActivity
| Description | (S)-Trolox is a water-soluble analogue of vitamin E, in which the phytyl chain is replaced with a carboxyl group. (S)-Trolox is frequently used as a model compound for studies of structural features, as well as a standard for evaluation of antioxidant activity. (S)-Trolox has potent and specific neuroprotective and antioxidant effects[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vitro | The neuroprotective efficacy of antioxidant molecules against iodoacetate (IAA) neurotoxicity in rat cerebellar granule cell (CGC) cultures is investigated. In the absence of MK-801, (S)-Trolox displays marginal neuroprotective effects. In the presence of MK-801 (10 μM), the neuroprotective efficacy of (S)-Trolox is greatly enhanced, giving rise to a recovery in MTT-reductase activity equivalent to 80–100% of control cultures. (S)-Trolox displays EC50 value of 78 μM. The fluorescence increase in IAA-stimulated DCFH-DA-loaded cultures is inhibited in a dose-dependent manner by the antioxidants (S)-Trolox with an IC50 value of 97 μM. The antioxidant (S)-Trolox demonstrate apotent and specific neuroprotective action in an in vitro model of neurodegeneration induced by inhibition of the glycolytic enzyme GAPDH[1]. |
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| References | [1]. Malcolm CS, et al. Characterization of iodoacetate-mediated neurotoxicity in vitro using primary cultures of rat cerebellar granule cells. Free Radic Biol Med. 2000 Jan 1;28(1):102-7. [2]. Górecki M, et al. Chromane helicity rule--scope and challenges based on an ECD study of various trolox derivatives. Org Biomol Chem. 2014 Apr 14;12(14):2235-54. |
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Chemical & Physical Properties
| Density | 1.219g/cm3 |
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| Boiling Point | 450.3ºC at 760 mmHg |
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| Melting Point | 160ºC (dec.)(lit.) |
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| Molecular Formula | C14H18O4 |
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| Molecular Weight | 250.29000 |
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| Flash Point | 171ºC |
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| Exact Mass | 250.12100 |
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| PSA | 66.76000 |
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| LogP | 2.48570 |
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| Index of Refraction | 1.567 |
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| InChIKey | GLEVLJDDWXEYCO-AWEZNQCLSA-N |
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| SMILES | Cc1c(C)c2c(c(C)c1O)CCC(C)(C(=O)O)O2 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26-37/39 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2932999099 |
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Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Articles1
More Articles
Chem. Lett. , 465, (1989)
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Synonyms
| UNII-O763YB84E3 |
| MFCD00180756 |
| (S)-(-)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid |
| (-)-(S)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid |
| (S)-(-)-Trolox |
| (S)-(-)-Trolox C |
| (S)-Trolox(TM) |
| (2S)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid |
