CAS 1270138-40-3|NSI-189

Introduction：Basic information about CAS 1270138-40-3|NSI-189, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. NSI-189 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	NSI-189
CAS Number	1270138-40-3	Molecular Weight	366.500
Density	1.1±0.1 g/cm3	Boiling Point	534.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀N₄O	Melting Point	/
MSDS	/	Flash Point	277.2±30.1 °C

Names

Name	(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone
Synonym	More Synonyms

NSI-189 BiologicalActivity

Description	NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.IC50 value:Target: in vitro: NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo. The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation [1] [2].in vivo: NSI-189 has been shown to increase the hippocampal volume of healthy adult mice by 20% [3].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. http://gizmodo.com/5874433/the-pill-that-could-cure-depression-by-growing-your-brain [2]. Compositions to effect neuronal growth US 8030492 B2 [3]. Why Neuralstem Could Provide A 10x Return

Description

NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.IC50 value:Target: in vitro: NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo. The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation [1] [2].in vivo: NSI-189 has been shown to increase the hippocampal volume of healthy adult mice by 20% [3].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. http://gizmodo.com/5874433/the-pill-that-could-cure-depression-by-growing-your-brain

[2]. Compositions to effect neuronal growth US 8030492 B2

[3]. Why Neuralstem Could Provide A 10x Return

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	534.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀N₄O
Molecular Weight	366.500
Flash Point	277.2±30.1 °C
Exact Mass	366.241974
PSA	48.47000
LogP	4.13
Appearance of Characters	white solid
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.601
InChIKey	DYTOQURYRYYNOR-UHFFFAOYSA-N
SMILES	CC(C)CCNc1ncccc1C(=O)N1CCN(Cc2ccccc2)CC1
Storage condition	-20℃

Synonyms

(4-Benzyl-1-piperazinyl){2-[(3-methylbutyl)amino]-3-pyridinyl}methanone

Methanone, [2-[(3-methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]-

unii-yve9u408zl

UNII:YVE9U408ZL

NSI-189

NSI189

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