CAS 119-34-6|2-nitro-4-aminophenol

Introduction：Basic information about CAS 119-34-6|2-nitro-4-aminophenol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles3
7. Synonyms

Common Name	2-nitro-4-aminophenol
CAS Number	119-34-6	Molecular Weight	154.123
Density	1.5±0.1 g/cm3	Boiling Point	334.5±27.0 °C at 760 mmHg
Molecular Formula	C₆H₆N₂O₃	Melting Point	125-127 °C(lit.)
MSDS	ChineseUSA	Flash Point	156.1±23.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	4-Amino-2-nitrophenol
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	334.5±27.0 °C at 760 mmHg
Melting Point	125-127 °C(lit.)
Molecular Formula	C₆H₆N₂O₃
Molecular Weight	154.123
Flash Point	156.1±23.7 °C
Exact Mass	154.037842
PSA	92.07000
LogP	0.64
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.689
InChIKey	WHODQVWERNSQEO-UHFFFAOYSA-N
SMILES	Nc1ccc(O)c([N+](=O)[O-])c1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ6303000

CHEMICAL NAME :: Phenol, 4-amino-2-nitro-

CAS REGISTRY NUMBER :: 119-34-6

BEILSTEIN REFERENCE NO. :: 1368435

LAST UPDATED :: 199701

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C6-H6-N2-O3

MOLECULAR WEIGHT :: 154.14

WISWESSER LINE NOTATION :: ZR DQ CNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 302 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 108 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 7680 ug/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12(Suppl 13),37,1988 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,43,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,43,1978 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1706 No. of Facilities: 1356 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 11981 (estimated) No. of Female Employees: 9309 (estimated)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S22-S24/25-S37/39-S26
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	SJ6303000
Hazard Class	6.1
HS Code	2922299090

Customs

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles3

Percutaneous absorption of nitroaromatic compounds: in vivo and in vitro studies in the human and monkey.

J. Invest. Dermatol. 84(3) , 180-3, (1985)

The percutaneous absorption of 2-nitro-p-phenylene-diamine, 4-amino-2-nitrophenol, nitrobenzene, p-nitroaniline, and 2,4-dinitrochlorobenzene was measured through human and monkey skin. Human studies ...

Plasma levels and kinetic disposition of 2,4-dinitrophenol and its metabolites 2-amino-4-nitrophenol and 4-amino-2-nitrophenol in the mouse.

J. Chromatogr. A. 344 , 177-86, (1985)

Eleven groups of six ICR mice were dosed orally with 22.5 mg/kg 2,4-dinitrophenol. Groups were sacrificed at 0, 0.5, 1, 2, 4, 6, 9, 12, 24, 48, and 96 h post-treatment and plasma was collected for ana...

The nonmutagenicity of purified 4-amino-2-nitrophenol in Salmonella typhimurium.

Carcinogenesis 3(7) , 809-13, (1982)

Two samples of 4-amino-2-nitrophenol were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100. Significant mutagenic activity was detected with a sample o...

Synonyms

2-hydroxy-5-aminonitrobenzene

5-amino-2-hydroxynitrobenzene

Phenol, 4-amino-2-nitro-

4-hydroxy-3-nitroaniline

4-Amino-2-nitrophenol

cioxidationbase25

2-nitro-4-aminophenol

fourrinebrownpr

fourrinebrownpropyl

EINECS 204-316-1

MFCD00007876

fourrine57

oxidationbase25

4-hydroxy-3-nitrobenzenamine

4-NH2-2-NO2-phenol

Aminonitrophenol

2-nitro-p-aminophenol

4-amino-2-nitrofenol

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