CAS 75288-96-9|Kukoamine A

Introduction：Basic information about CAS 75288-96-9|Kukoamine A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Kukoamine A BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Kukoamine A
CAS Number	75288-96-9	Molecular Weight	530.656
Density	1.2±0.1 g/cm3	Boiling Point	872.1±65.0 °C at 760 mmHg
Molecular Formula	C₂₈H₄₂N₄O₆	Melting Point	/
MSDS	/	Flash Point	481.2±34.3 °C

Names

Name	N1,N12-bis(dihydrocaffeoyl)spermine
Synonym	More Synonyms

Kukoamine A BiologicalActivity

Description	Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others
Target	Ki: 1.8 μM (Trypanothione reductase)[1]
References	[1]. Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 ( Pt 2):371-5.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	872.1±65.0 °C at 760 mmHg
Molecular Formula	C₂₈H₄₂N₄O₆
Molecular Weight	530.656
Flash Point	481.2±34.3 °C
Exact Mass	530.310425
PSA	163.18000
LogP	-0.17
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.588
InChIKey	IOLDDENZPBFBHV-UHFFFAOYSA-N
SMILES	O=C(CCc1ccc(O)c(O)c1)NCCCNCCCCNCCCNC(=O)CCc1ccc(O)c(O)c1

Synonyms

.N1,N14-bis(dihydrocaffeoyl)spermine

Kukoamine A

N,N'-[butane-1,4-diylbis(iminopropane-3,1-diyl)]bis[3-(3,4-dihydroxyphenyl)propanamide]

bis-dihydrocaffeoylspermine

N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3-(3,4-dihydroxyphenyl)propanamide]

Benzenepropanamide, N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-

.kukoamine A

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