Introduction：Basic information about CAS 957209-68-6|NVP-QAV-572, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NVP-QAV-572 |
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| CAS Number | 957209-68-6 | Molecular Weight | 471.50500 |
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| Density | 1.59±0.1 g/cm3 (20 °C, 760 mmHg) | Boiling Point | / |
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| Molecular Formula | C17H19F2N7O3S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Urea, N-[2-[2-(2-fluoroethyl)-2H-tetrazol-5-yl]ethyl]-N'-[5-[3-fluoro-4-(methylsulfonyl)phenyl]-4-methyl-2-thiazolyl] |
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| Synonym | More Synonyms |
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NVP-QAV-572 BiologicalActivity
| Description | NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC50 of 10 nM. |
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| Related Catalog | Research Areas >>Cancer |
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| Target | PI3K:10 nM (IC50) |
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| In Vitro | NVP-QAV-572 (Example 8) is useful in the treatment of conditions which are mediated by the activation of the Pi3 kinase enzymes, particularly inflammatory or allergic conditions[1]. |
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| References | [1]. Emma Budd, et al. 5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase inhibitors. US 7998990 B2. |
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Chemical & Physical Properties
| Density | 1.59±0.1 g/cm3 (20 °C, 760 mmHg) |
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| Molecular Formula | C17H19F2N7O3S2 |
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| Molecular Weight | 471.50500 |
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| Exact Mass | 471.09600 |
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| PSA | 168.38000 |
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| LogP | 3.52600 |
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| InChIKey | UGEZRRNNFHAJTM-UHFFFAOYSA-N |
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| SMILES | Cc1nc(NC(=O)NCCc2nnn(CCF)n2)sc1-c1ccc(S(C)(=O)=O)c(F)c1 |
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| Storage condition | 2-8℃ |
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Synonyms
