Introduction：Basic information about CAS 834903-43-4|CID 16020046, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CID 16020046 |
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| CAS Number | 834903-43-4 | Molecular Weight | 425.43600 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C25H19N3O4 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | Benzoic acid, 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl] |
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| Synonym | More Synonyms |
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CID 16020046 BiologicalActivity
| Description | CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist; inhibitsGPR55 constitutive activity with IC50 of 0.15 uM.IC50 value: 0.15 uM [1]Target: GPR55 antagonistIn yeast cells expressing human GPR55, CID16020046 antagonized agonist-induced receptor activation. In human embryonic kidney(HEK293) cells stably expressing human GPR55, the compound behaved as an antagonist on LPI-mediated Ca2+ release and extracellular signal-regulated kinases activation, but not in HEK293 cells expressing cannabinoid receptor 1 or 2.CID16020046 concentration dependently inhibited LPI-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor k of activated B cells (NF-kB) and serum response element, translocation of NFAT and NF-kB, and GPR55 internalization. It reduced LPI-induced wound healing in primary human lung microvascular endothelial cells and reversed LPI-inhibited platelet aggregation. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>GPR55Research Areas >>Others |
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| References | [1]. Kargl J, et al. A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66. |
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Chemical & Physical Properties
| Molecular Formula | C25H19N3O4 |
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| Molecular Weight | 425.43600 |
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| Exact Mass | 425.13800 |
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| PSA | 106.52000 |
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| LogP | 4.60370 |
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| InChIKey | VGUQVYZXABOXCX-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(-c2n[nH]c3c2C(c2cccc(O)c2)N(c2ccc(C(=O)O)cc2)C3=O)cc1 |
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| Storage condition | -20℃ |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319 |
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| Precautionary Statements | P305 + P351 + P338 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
