Introduction：Basic information about CAS 90-50-6|3,4,5-Trimethoxycinnamic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
3,4,5-Trimethoxycinnamic acid (10 μg/ml) increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
In Vivo
3,4,5-Trimethoxycinnamic acid (25-100 mg/kg, i.p.) exhibits sedative effect, and prolongs the sleeping time in rats[1]. 3,4,5-Trimethoxycinnamic acid (10 mg/kg, p.o.) significantly decreases locomotor activity in mice[2].
References
[1]. Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9.
[2]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.
Chemical & Physical Properties
Density
1.2±0.1 g/cm3
Boiling Point
396.4±37.0 °C at 760 mmHg
Melting Point
125-127 °C(lit.)
Molecular Formula
C12H14O5
Molecular Weight
238.237
Flash Point
151.5±20.0 °C
Exact Mass
238.084122
PSA
64.99000
LogP
2.00
Vapour Pressure
0.0±1.0 mmHg at 25°C
Index of Refraction
1.560
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
GE0722000
CHEMICAL NAME :
Cinnamic acid, 3,4,5-trimethoxy-
CAS REGISTRY NUMBER :
90-50-6
BEILSTEIN REFERENCE NO. :
1537834
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H14-O5
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
422 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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