CAS 1198-55-6|3,4,5,6-Tetrachlorobenzene-1,2-diol
| Common Name | 3,4,5,6-Tetrachlorobenzene-1,2-diol | ||
|---|---|---|---|
| CAS Number | 1198-55-6 | Molecular Weight | 247.891 |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 309.1±37.0 °C at 760 mmHg |
| Molecular Formula | C6H2Cl4O2 | Melting Point | 184-186°C (dec.) |
| MSDS | USA | Flash Point | 140.7±26.5 °C |
| Symbol | GHS05, GHS07, GHS09 | Signal Word | Danger |
Names
| Name | tetrachlorocatechol |
|---|---|
| Synonym | More Synonyms |
3,4,5,6-Tetrachlorobenzene-1,2-diol BiologicalActivity
| Description | Tetrachlorocatechol is a metabolite of pentachlorophenol. Tetrachlorocatechol is one of the most toxic chlorinated catechol produced by the chlorobleaching of pulp and frequently found in the kraft pulp mill effluents[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. G. Renner, et al. Acute toxicities of pentachlorophenol, pentachloroanisole, tetrachlorohydroquinone, tetrachlorocatechol, tetrachlororesorcinol, tetrachlorodimethoxybenzenes and tetrachlorobenzenediol diacetates administered to mice, Toxicological & Environmental Chemistry, 11:1, 37-50. [2]. Mukherjee, et al. Evaluation of Acute Toxicity Levels and Ethological Responses Under Tetrachlorocatechol Exposure in Common Carp, Cyprinus carpio (Linnaeus). Proc Zool Soc 67, 108–113 (2014). |
Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 309.1±37.0 °C at 760 mmHg |
| Melting Point | 184-186°C (dec.) |
| Molecular Formula | C6H2Cl4O2 |
| Molecular Weight | 247.891 |
| Flash Point | 140.7±26.5 °C |
| Exact Mass | 245.880890 |
| PSA | 40.46000 |
| LogP | 4.74 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.662 |
| InChIKey | RRBMVWQICIXSEO-UHFFFAOYSA-N |
| SMILES | Oc1c(O)c(Cl)c(Cl)c(Cl)c1Cl |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,526,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,526,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 318 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness
- REFERENCE :
- TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981- Volume(issue)/page/year: 11,37,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 136 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,63,1978
Safety Information
| Symbol | GHS05, GHS07, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H318-H400 |
| Precautionary Statements | P273-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/22 |
| Safety Phrases | S26-S36/37/39-S39 |
| RIDADR | 2811 |
| RTECS | UX2449000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2908199090 |
Customs
| HS Code | 2908199090 |
|---|---|
| Summary | HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0% |
Articles9
More Articles| Polyhalogenated benzo- and naphthoquinones are potent inhibitors of plant and bacterial ureases. FEBS Lett. 555(2) , 367-70, (2003) Polyhalogenated benzo- and naphthoquinones were found to be potent inhibitors of pure ureases from Bacillus pasteurii and Canavalia ensiformis. They also inhibited ureases in whole cells of Helicobact... | |
| Oxidative double dehalogenation of tetrachlorocatechol by a bio-inspired CuII complex: formation of chloranilic acid. Chemistry 14(18) , 5567-76, (2008) Copper(II) complexes of the potentially tripodal N,N,O ligand 3,3-bis(1-methylimidazol-2-yl)propionate (L1) and its conjugate acid HL1 have been synthesised and structurally and spectroscopically char... | |
| Synergistic cytotoxic effect of tetrachlorocatechol and sodium azide in Escherichia coli: toxicity, metabolism, and mechanistic aspects. Environ. Toxicol. Chem. 28(7) , 1380-9, (2009) Pentachlorophenol (PCP) is used in industrial and domestic applications, including as a biocide and a wood preservative. Metabolism of PCP undergoes oxidative dechlorination, forming tetrachlorocatech... |
Synonyms
| 1,2-Benzenediol, 3,4,5,6-tetrachloro- |
| MFCD00002190 |
| 3,4,5,6-Tetrachloro-1,2-benzenediol (9CI) |
| 3,4,5,6-tetrachlorobenzene-1,2-diol |
| 3,4,5,6-Tetrachloro-1,2-benzenediol |
| TETRACHLOROCATECHOL |
