CAS 113276-94-1|h-8 dihydrochloride

Introduction:Basic information about CAS 113276-94-1|h-8 dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Nameh-8 dihydrochloride
CAS Number113276-94-1Molecular Weight338.25300
Density/Boiling Point473.9ºC at 760 mmHg
Molecular FormulaC12H17Cl2N3O2SMelting Point221-222℃ (methanol water )
MSDSUSAFlash Point240.4ºC

Names

NameN-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride
SynonymMore Synonyms

h-8 dihydrochloride BiologicalActivity

DescriptionH-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>PKASignaling Pathways >>Stem Cell/Wnt >>PKA
References

[1]. Niisato N, et al. Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms. Life Sci. 1999;65(10):PL109-14.

Chemical & Physical Properties

Boiling Point473.9ºC at 760 mmHg
Melting Point221-222℃ (methanol water )
Molecular FormulaC12H17Cl2N3O2S
Molecular Weight338.25300
Flash Point240.4ºC
Exact Mass337.04200
PSA79.47000
LogP4.19910
Vapour Pressure3.79E-09mmHg at 25°C
InChIKeyRJJLZYZEVNCZIW-UHFFFAOYSA-N
SMILESCNCCNS(=O)(=O)c1cccc2cnccc12.Cl.Cl
Storage condition2-8°C
Water Solubilityethanol: 25 mg/mL, clear, colorless

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety PhrasesS22-S24/25
RIDADRNONH for all modes of transport
WGK Germany3
HS Code2935009090

Customs

HS Code2935009090
Summary2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles2

More Articles
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

Biochemistry 23 , 5036-5041, (1984)

Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the...

In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

Mol. Cell. Biol. 9 , 2424, (1989)

We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interle...

Synonyms

H-8 dihydrochloride
MFCD00036962
CAS 96541-83-2|QUINOLINE-5-CARBOXYLIC ACID HYDRAZIDE
CAS 16686-11-6|2-(3-Chloropropyl)-1,3-dioxolane
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