CAS 9005-35-0|Calcium alginate
| Common Name | Calcium alginate | ||
|---|---|---|---|
| CAS Number | 9005-35-0 | Molecular Weight | 1170.93000 |
| Density | 2.1173 g/cm3 | Boiling Point | / |
| Molecular Formula | C36H42Ca3O36 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Alginic Acid Calcium Salt |
|---|---|
| Synonym | More Synonyms |
Calcium alginate BiologicalActivity
| Description | Calcium alginate is a biopolymer that can be used for developing oral drug-delivery systems[1]. Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| In Vitro | Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media. This enables the hydrogel to absorb and release aqueous solutions at certain ranges of pH values. By absorbing an aqueous solution containing a drug, an active drug release can be triggered at a specified range of pH value[2]. Calcium alginate is a biodegradable gel-transforming agent widely used for nasal packing. It can reduce pain and improve comfort[3]. |
| References | [1]. Demitri C, et al. Encapsulation of Lactobacillus kefiri in alginate microbeads using a double novel aerosol technique. Mater Sci Eng C Mater Biol Appl. 2017;77:548-555. [2]. Chengzhi Hu, et al. Electrosynthesis of magnetoresponsive microrobot for targeted drug delivery using calcium alginate. Annu Int Conf IEEE Eng Med Biol Soc. 2016;2016:2111-2114. [3]. Park DY, et al. Comparison of calcium alginate and carboxymethyl cellulose for nasal packing after endoscopic sinus surgery: a prospective, randomised, controlled single-blinded trial. Clin Otolaryngol. 2016;41(3):234-240. |
Chemical & Physical Properties
| Density | 2.1173 g/cm3 |
|---|---|
| Molecular Formula | C36H42Ca3O36 |
| Molecular Weight | 1170.93000 |
| Exact Mass | 1170.03000 |
| PSA | 511.32000 |
| InChIKey | OKHHGHGGPDJQHR-PXGLGWDYSA-L |
| SMILES | O=C([O-])C1OC(OC2C(C(=O)O)OC(OC3C(C(=O)[O-])OC(O)C(O)C3O)C(O)C2O)C(O)C(O)C1O.[Ca+2] |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1407 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,381,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 64 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,381,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83092 No. of Facilities: 47 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83092 No. of Facilities: 643 (estimated) No. of Industries: 16 No. of Occupations: 7 No. of Employees: 3968 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AZ5820000 |
Articles72
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Synonyms
| calcium,(2S,3S,4S,5S,6R)-6-[(2R,3S,4R,5S,6R)-2-carboxy-6-[(2R,3S,4R,5S,6R)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate |
| MFCD00143567 |
