CAS 425671-29-0|LY518674
Introduction：Basic information about CAS 425671-29-0|LY518674, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LY518674 | ||
|---|---|---|---|
| CAS Number | 425671-29-0 | Molecular Weight | 409.47800 |
| Density | 1.21g/cm3 | Boiling Point | 575.852ºC at 760 mmHg |
| Molecular Formula | C23H27N3O4 | Melting Point | / |
| MSDS | / | Flash Point | 302.065ºC |
Names
| Name | 2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid |
|---|---|
| Synonym | More Synonyms |
LY518674 BiologicalActivity
| Description | LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42 nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>PPARResearch Areas >>Metabolic Disease |
| Target | EC50: 42 nM (human PPARα)[1] |
| In Vivo | LY518674 reduces triglycerides and increased HDL-C in vivo[2]. LY518674 substantially increases apolipoprotein A-I (apoA-I) turnover without major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) [3]. |
| References | [1]. Bravo Y, et al. Identification of the first potent, selective and bioavailable PPARα antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. [2]. Nissen SE, et al. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. JAMA. 2007 Mar 28;297(12):1362-73. [3]. Khera AV, et al. Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. Eur Heart J. 2015 Nov 14;36(43):3020-2. |
Chemical & Physical Properties
| Density | 1.21g/cm3 |
|---|---|
| Boiling Point | 575.852ºC at 760 mmHg |
| Molecular Formula | C23H27N3O4 |
| Molecular Weight | 409.47800 |
| Flash Point | 302.065ºC |
| Exact Mass | 409.20000 |
| PSA | 97.21000 |
| LogP | 3.34540 |
| Index of Refraction | 1.594 |
| Storage condition | 2-8°C |
Synonyms
| 2-Methyl-2-[4-[3-[1-(4-Methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl]phenoxy]propionic acid |
| Propanoic acid,2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methyl |
| 2-[4-[3-[4,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methylpropanoic acid |
| 2-[4-[3-[2,5-dihydro-1-[(4-methylphenyl)methyl]-5-oxo-1H-1,2,4-triazol-3-yl]propyl]phenoxy]-2-methyl-propanoic acid |
