CAS 217099-44-0|BCX 1470 (methanesulfonate)

Introduction：Basic information about CAS 217099-44-0|BCX 1470 (methanesulfonate), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BCX 1470 (methanesulfonate) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	BCX 1470 (methanesulfonate)
CAS Number	217099-44-0	Molecular Weight	398.47700
Density	/	Boiling Point	509.9ºC at 760 mmHg
Molecular Formula	C₁₅H₁₄N₂O₅S₃	Melting Point	/
MSDS	/	Flash Point	262.2ºC

Names

Name	2-Thiophenecarboxylic acid 2-(aminoiminomethyl)benzo[b]thiophen-6-yl ester methanesulfonate (1:1)
Synonym	More Synonyms

BCX 1470 (methanesulfonate) BiologicalActivity

Description	BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.
Related Catalog	Signaling Pathways >>Immunology/Inflammation >>Complement SystemResearch Areas >>Inflammation/Immunology
References	[1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468 [2]. Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE.The Arthus reaction in rodents: species-specific requirement of complement.J Immunol. 2000 Jan 1;164(1):463-8.

Description

BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.

Related Catalog

Signaling Pathways >>Immunology/Inflammation >>Complement SystemResearch Areas >>Inflammation/Immunology

References

[1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468

[2]. Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE.The Arthus reaction in rodents: species-specific requirement of complement.J Immunol. 2000 Jan 1;164(1):463-8.

Chemical & Physical Properties

Boiling Point	509.9ºC at 760 mmHg
Molecular Formula	C₁₅H₁₄N₂O₅S₃
Molecular Weight	398.47700
Flash Point	262.2ºC
Exact Mass	398.00600
PSA	195.40000
LogP	4.85090
InChIKey	MCPAUXMAIOICMC-UHFFFAOYSA-N
SMILES	CS(=O)(=O)O.N=C(N)c1cc2ccc(OC(=O)c3cccs3)cc2s1
Storage condition	2-8℃

Synonyms

BCX 1470 methanesulfonate

BCX 1470 (methanesulfonate)

Recommended......