Introduction：Basic information about CAS 915365-57-0|Cot inhibitor-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cot inhibitor-1 |
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| CAS Number | 915365-57-0 | Molecular Weight | 553.46100 |
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| Density | 1.42g/cm3 | Boiling Point | 729.961ºC at 760 mmHg |
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| Molecular Formula | C27H27Cl2FN8 | Melting Point | / |
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| MSDS | / | Flash Point | 395.267ºC |
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Names
| Name | 6-[[1-[2-(azepan-1-yl)ethyl]triazol-4-yl]methylamino]-8-chloro-4-(3-chloro-4-fluoroanilino)quinoline-3-carbonitrile |
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| Synonym | More Synonyms |
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Cot inhibitor-1 BiologicalActivity
| Description | Cot inhibitor-1 is a COT/Tpl2 inhibitor. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>TNF ReceptorResearch Areas >>Cancer |
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| References | [1]. Wu, Junjun et al Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-production in human whole blood.Bioorganic & Medicinal Chemistry Letters (2009), 19(13), 3485-3488. |
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Chemical & Physical Properties
| Density | 1.42g/cm3 |
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| Boiling Point | 729.961ºC at 760 mmHg |
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| Molecular Formula | C27H27Cl2FN8 |
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| Molecular Weight | 553.46100 |
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| Flash Point | 395.267ºC |
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| Exact Mass | 552.17200 |
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| PSA | 94.69000 |
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| LogP | 6.45948 |
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| Index of Refraction | 1.692 |
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| InChIKey | ZWFKJFUFYPOTKL-UHFFFAOYSA-N |
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| SMILES | N#Cc1cnc2c(Cl)cc(NCc3cn(CCN4CCCCCC4)nn3)cc2c1Nc1ccc(F)c(Cl)c1 |
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Synonyms
| 6-[[[1-[2-(AZEPAN-1-YL)ETHYL]-1H-1,2,3-TRIAZOL-4-YL]METHYL]AMINO]-8-CHLORO-4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]QUINOLINE-3-CARBONITRILE |
| Cot inhibitor-1 |
| substituted 6-aminoquinoline-3-carbonitrile,28 |
