CAS 5577-13-9|Ethyl [(4-methylphenyl)sulfonyl]carbamate

Introduction：Basic information about CAS 5577-13-9|Ethyl [(4-methylphenyl)sulfonyl]carbamate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Ethyl [(4-methylphenyl)sulfonyl]carbamate
CAS Number	5577-13-9	Molecular Weight	243.279
Density	1.3±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₀H₁₃NO₄S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Ethyl N-(4-methylphenyl)sulfonylcarbamate
Synonym	More Synonyms

BiologicalActivity

Description	Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].
Related Catalog	Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel
References	[1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27. [2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476–1478. [3]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.

Description

Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3].

Related Catalog

Research Areas >>Metabolic DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel

References

[1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27.

[2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476–1478.

[3]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Molecular Formula	C₁₀H₁₃NO₄S
Molecular Weight	243.279
Exact Mass	243.056534
PSA	80.85000
LogP	1.86
Index of Refraction	1.530
InChIKey	DFWQXANLGSXMKF-UHFFFAOYSA-N
SMILES	CCOC(=O)NS(=O)(=O)c1ccc(C)cc1

Safety Information

Hazard Codes	Xi
HS Code	2935009090

Customs

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Synonyms

Tosylcarbamic acid ethyl ester

Ethyl [(4-methylphenyl)sulfonyl]carbamate

ethyl N-(4-toluenesulfonyl)carbamate

ethyl tosylcarbaMate

Ethyl [(4-methylphenyl)sulphonyl]carbamate

Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, ethyl ester

Tosylurethane

ethoxycarbonamide of p-toluenebenzenesulfoacid

ethyl p-tosylcarbamate

(toluene-4-sulfonyl)-carbamic acid ethyl ester

ethyl N-(tosyl)carbamate

Carbamic acid, [(4-methylphenyl)sulfonyl]-, ethyl ester

N-(4-methylphenyl)sulfonylcarbamic acid ethyl ester

2OVMSWR D1

N-(p-Tolylsulfonyl)carbamic acid ethyl ester

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