Introduction：Basic information about CAS 20724-73-6|2'-C-Methylcytidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2'-C-Methylcytidine |
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| CAS Number | 20724-73-6 | Molecular Weight | 257.243 |
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| Density | 1.7±0.1 g/cm3 | Boiling Point | 523.9±60.0 °C at 760 mmHg |
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| Molecular Formula | C10H15N3O5 | Melting Point | 243-245ºC |
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| MSDS | ChineseUSA | Flash Point | 270.7±32.9 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one |
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| Synonym | More Synonyms |
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2'-C-Methylcytidine BiologicalActivity
| Description | NM107 is a inhibitors of HCV RNA replication with IC50 of 7.0 μM in vitro.IC50 value: 7.0 μMTarget:HCV RNA replicationNM107 is a potent and selective inhibitor of flavi- and pesti-virus replication in cell culture, with inhibitory activity and cytotoxicity against HCV 1b replicon cells, IC50 is 1.13 μM. Intracellular HCV RNA in HCV-infected cells treated the HCV polymerase inhibitor NM107 shows a similar pattern of decline. NM107 are currently being investigated as additional therapeutic agents for HCV infection. NM107 inhibits bovine viral diarrhea virus (BVDV) replication (EC50 0.67 nM), eliminates persistent BVDV infection at nontoxic concentrations. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HCVResearch Areas >>Infection |
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| References | [1]. McCown MF, et al. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleosidepolymerase or protease inhibitors. Antimicrob Agents Chemother. 2008 May;52(5):1604-1612. |
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Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
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| Boiling Point | 523.9±60.0 °C at 760 mmHg |
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| Melting Point | 243-245ºC |
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| Molecular Formula | C10H15N3O5 |
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| Molecular Weight | 257.243 |
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| Flash Point | 270.7±32.9 °C |
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| Exact Mass | 257.101166 |
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| PSA | 130.83000 |
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| LogP | -0.80 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.700 |
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| InChIKey | PPUDLEUZKVJXSZ-VPCXQMTMSA-N |
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| SMILES | CC1(O)C(O)C(CO)OC1n1ccc(N)nc1=O |
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| Storage condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
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| Water Solubility | H2O: >20mg/mL |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| valopicitabine |
| 2-C-METHYLCYTIDINE |
| 2'-C-Methyl Cytidine |
| Cytidine,2'-C-methyl |
| 2'-METHYLCYTIDINE |
| NM107 |
| Cytidine, 2'-C-methyl- |
| UNII-27FS20C1D8 |
| 1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-4-aminopyrimidin-2(1H)-one |
| UNII:27FS20C1D8 |
| 2'-C-methylcytidine |
