CAS 841-77-0|N-Benzhydrylpiperazine

Introduction：Basic information about CAS 841-77-0|N-Benzhydrylpiperazine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles11
7. Synonyms

Common Name	N-Benzhydrylpiperazine
CAS Number	841-77-0	Molecular Weight	252.354
Density	1.1±0.1 g/cm3	Boiling Point	365.1±32.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₀N₂	Melting Point	90-93 °C
MSDS	ChineseUSA	Flash Point	140.5±16.1 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	Benzhydrylpiperazine
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	365.1±32.0 °C at 760 mmHg
Melting Point	90-93 °C
Molecular Formula	C₁₇H₂₀N₂
Molecular Weight	252.354
Flash Point	140.5±16.1 °C
Exact Mass	252.162643
PSA	15.27000
LogP	2.85
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.584
InChIKey	NWVNXDKZIQLBNM-UHFFFAOYSA-N
SMILES	c1ccc(C(c2ccccc2)N2CCNCC2)cc1
Water Solubility	0.45 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6465000

CHEMICAL NAME :: Piperazine, 1-(diphenylmethyl)-

CAS REGISTRY NUMBER :: 841-77-0

BEILSTEIN REFERENCE NO. :: 0222773

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H20-N2

MOLECULAR WEIGHT :: 252.39

WISWESSER LINE NOTATION :: T6M DNTJ DYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 31,453,1972

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TL6465000
Packaging Group	I; II; III
HS Code	2942000000

Customs

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles11

Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(9-10) , 605-9, (2011)

A rapid and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed and validated for quantification of cyclizine and its main metabolite norcyclizine in human plasma. Sam...

Oxidative metabolism of cinnarizine in rat liver microsomes.

Biochem. Pharmacol. 44(7) , 1471-4, (1992)

The oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] to 1-(diphenylmethyl)piperazine (M-1), 1-(diphenylmethyl)-4-[3-(4'-hydroxyphenyl)-2-propenyl]pipera...

The reactions of polyhalogenated-2-nitro-1, 3-butadiene with alkylthio, thiomorpholine and piperazine derivatives. Ibis C and Deniz NG.

Indian J. Chem. B 47(9) , 1407, (2008)

Synonyms

Piperazine, 1-(diphenylmethyl)-

EINECS 212-667-7

N-Benzhydrylpiperazine

1-benzhydrylpiperazine

MFCD00038379

Piperazine, 1- (diphenylmethyl)-

1-(Diphenylmethyl)piperazine

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