Introduction：Basic information about CAS 26844-12-2|Indoramin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Indoramin |
|---|
| CAS Number | 26844-12-2 | Molecular Weight | 347.45300 |
|---|
| Density | 1.21g/cm3 | Boiling Point | 600ºC at 760mmHg |
|---|
| Molecular Formula | C22H25N3O | Melting Point | 208-210° |
|---|
| MSDS | / | Flash Point | 316.7ºC |
|---|
Names
| Name | N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide |
|---|
| Synonym | More Synonyms |
|---|
Indoramin BiologicalActivity
| Description | Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor[1]. |
|---|
| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
|---|
| References | [1]. M Eltze, et al. In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73. |
|---|
Chemical & Physical Properties
| Density | 1.21g/cm3 |
|---|
| Boiling Point | 600ºC at 760mmHg |
|---|
| Melting Point | 208-210° |
|---|
| Molecular Formula | C22H25N3O |
|---|
| Molecular Weight | 347.45300 |
|---|
| Flash Point | 316.7ºC |
|---|
| Exact Mass | 347.20000 |
|---|
| PSA | 48.13000 |
|---|
| LogP | 3.93360 |
|---|
| Vapour Pressure | 2.36E-14mmHg at 25°C |
|---|
| Index of Refraction | 1.657 |
|---|
| InChIKey | JXZZEXZZKAWDSP-UHFFFAOYSA-N |
|---|
| SMILES | O=C(NC1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccccc1 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CV5395900
- CHEMICAL NAME :
- Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)-
- CAS REGISTRY NUMBER :
- 26844-12-2
- BEILSTEIN REFERENCE NO. :
- 0494035
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C22-H25-N3-O
- MOLECULAR WEIGHT :
- 347.50
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >400 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1054,1971
|
Safety Information
Customs
| HS Code | 2933990090 |
|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Synonyms
| 3-<2-(4-Benzamidopiperid-1-yl)ethyl>indol |
| Indoramine [INN-French] |
| N-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-benzamide |
| 3-[2-(4-benzamido-1-piperidyl)ethyl]indole |
| INDORAMIN |
| Indoramine |
| 3-[2-(4-benzamidopiperid-1-yl)ethyl]indole |
| Indoramina [INN-Spanish] |
| EINECS 248-041-5 |
| Benzamide,N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl) |
| Indoraminum [INN-Latin] |
