Introduction：Basic information about CAS 75225-51-3|LOVASTATIN HYDROXY ACID, SODIUM SALT, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LOVASTATIN HYDROXY ACID, SODIUM SALT |
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| CAS Number | 75225-51-3 | Molecular Weight | 422.55 |
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| Density | 1.14g/cm3 | Boiling Point | 602.3ºC at 760 mmHg |
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| Molecular Formula | C24H38O6 | Melting Point | / |
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| MSDS | / | Flash Point | 199.1ºC |
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Names
| Name | mevinolinic acid |
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| Synonym | More Synonyms |
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LOVASTATIN HYDROXY ACID, SODIUM SALT BiologicalActivity
| Description | Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>HMG-CoA Reductase (HMGCR) |
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| Target | Ki: 0.6 nM (HMG-CoA reductase)[1] |
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| References | [1]. Alberts AW, et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61. |
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Chemical & Physical Properties
| Density | 1.14g/cm3 |
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| Boiling Point | 602.3ºC at 760 mmHg |
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| Molecular Formula | C24H38O6 |
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| Molecular Weight | 422.55 |
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| Flash Point | 199.1ºC |
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| Exact Mass | 447.26800 |
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| PSA | 106.89000 |
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| LogP | 2.38090 |
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| Index of Refraction | 1.537 |
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| InChIKey | QLJODMDSTUBWDW-BXMDZJJMSA-N |
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| SMILES | CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC(O)CC(O)CC(=O)O)C21 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- QJ7180000
- CHEMICAL NAME :
- 1-Naphthaleneheptanoic aicd, 1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimet hyl-8- (2-methyl-1-oxobutoxy)-, ammonium salt, (1S-(1-alpha(beta-S*,delta-S*),2-alpha,6-beta, 8-beta(R*),8a-beta))-
- CAS REGISTRY NUMBER :
- 75225-51-3
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C24-H38-O6.H3-N
- MOLECULAR WEIGHT :
- 439.66
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 749 mg/kg
- SEX/DURATION :
- female 6-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,449,1983
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Synonyms
| 2-methoxy-4,4'-dihydroxychalcone |
| Echinantin |
| 4',4-dihydroxy-2-methoxychalcone |
| LOVASTATIN HYDROXY ACID, SODIUM SALT |
| Echinatin |
| Mevinolinic acid |
| lovastatin acid |
| loureirin C |
| lovastatin hydroxy acid |
