CAS 67224-41-3|ACTH (4-11)

Introduction：Basic information about CAS 67224-41-3|ACTH (4-11), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. ACTH (4-11) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	ACTH (4-11)
CAS Number	67224-41-3	Molecular Weight	1090.26000
Density	1.46 g/cm3	Boiling Point	/
Molecular Formula	C₅₀H₇₁N₁₅O₁₁S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	acth (4-11)
Synonym	More Synonyms

ACTH (4-11) BiologicalActivity

Description	ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic DiseasePeptides
In Vitro	α-melanocyte stimulating hormone (MSH) induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. Adrenocorticotropic hormone (ACTH) possesses the same amino acid sequence as MSH does. α-MSH induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. ACTH (4-11) loses almost all activity for the binding to melanocortin receptor 1 (MC1R)[1].
References	[1]. Hirobe T, et al. ACTH(4-12) is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J Exp Zool. 2000 May 1;286(6):632-40.

Chemical & Physical Properties

Density	1.46 g/cm3
Molecular Formula	C₅₀H₇₁N₁₅O₁₁S
Molecular Weight	1090.26000
Exact Mass	1089.52000
PSA	462.01000
LogP	3.69380
Index of Refraction	1.682
InChIKey	ZKBNJKUZBFBIKV-UHFFFAOYSA-N
SMILES	CSCCC(N)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(CCCCN)C(=O)O
Storage condition	2-8℃

Synonyms

Methionyl-glutamyl-histidinyl-phenylalanyl-argininyl-tryptophanyl-glycinyl-lysine

MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS

H-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-OH

MEHFRWGK

ADRENOCORTICOTROPIC HORMONE FRAGMENT 4-11

MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS

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