Introduction：Basic information about CAS 85-61-0|Coenzyme A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Coenzyme A |
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| CAS Number | 85-61-0 | Molecular Weight | 767.534 |
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| Density | 2.0±0.1 g/cm3 | Boiling Point | 146 - 147 |
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| Molecular Formula | C21H36N7O16P3S | Melting Point | -5ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | coenzyme A |
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| Synonym | More Synonyms |
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Coenzyme A BiologicalActivity
| Description | Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| References | [1]. Baković J, et al. A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification. Mol Cell Biochem. 2019 Aug 2. |
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Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
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| Boiling Point | 146 - 147 |
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| Melting Point | -5ºC |
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| Molecular Formula | C21H36N7O16P3S |
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| Molecular Weight | 767.534 |
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| Exact Mass | 767.115234 |
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| PSA | 414.79000 |
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| LogP | -4.02 |
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| Index of Refraction | 1.737 |
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| InChIKey | RGJOEKWQDUBAIZ-LMNWYZMXSA-N |
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| SMILES | CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS |
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| Storage condition | −20°C |
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Safety Information
| Safety Phrases | S24/25 |
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| WGK Germany | 3 |
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Synonyms
| Coalip |
| COA-SH |
| coenzyme-A |
| EINECS 201-619-0 |
| CoASH |
| Lucina |
| [(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydro-2-furanyl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate |
| CoA |
| Thiol-CoA |
| co-enzyme-A |
| MFCD06795839 |
| HSCoA |
| HS-CoA |
| CONENZYME A |
| Coenzyme A |
| Aluzime |
| Adenosine, 5'-O-[hydroxy[[hydroxy[(3R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutoxy]phosphinyl]oxy]phosphinyl]-, 3'-(dihydrogen phosphate) |
| Coenzym A |
