Introduction：Basic information about CAS 70833-07-7|Prifuroline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Prifuroline |
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| CAS Number | 70833-07-7 | Molecular Weight | 228.29000 |
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| Density | 1.18g/cm3 | Boiling Point | 383.8ºC at 760 mmHg |
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| Molecular Formula | C14H16N2O | Melting Point | / |
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| MSDS | / | Flash Point | 185.9ºC |
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Names
Prifuroline BiologicalActivity
| Description | Prifuroline is an antiarrhythmic agent. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease |
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| In Vivo | Prifuroline is an antiarrhythmic agent. Prifuroline dose-dependently antagonizes the arrhythmogenic action of aconitine in rats, when administered either intravenously (5, 10 or 20 mg/kg) or intraduodenally (10, 20 or 50 mg/kg). Prifuroline also diminishes ventricular susceptibility to electrical stimulation in open-chest rats. The arrhythmias induced in dogs by coronary artery ligation are markedly antagonized by Prifuroline after doses of 5 and 10 mg/kg i.v. or 30 mg/kg intraduodenally. The duration of its antiarrhythmic activity in this model of arrhythmias in conscious dogs is much longer after intraduodenal than after i.v. administration[1]. |
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| References | [1]. Benharkate M, et al. Antiarrhythmic and hemodynamic effects of prifuroline. Arzneimittelforschung. 1986 Dec;36(12):1761-7. |
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Chemical & Physical Properties
| Density | 1.18g/cm3 |
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| Boiling Point | 383.8ºC at 760 mmHg |
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| Molecular Formula | C14H16N2O |
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| Molecular Weight | 228.29000 |
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| Flash Point | 185.9ºC |
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| Exact Mass | 228.12600 |
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| PSA | 28.74000 |
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| LogP | 2.31580 |
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| Index of Refraction | 1.617 |
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| InChIKey | IYMLHOSZPZHXCR-UHFFFAOYSA-N |
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| SMILES | CN(C)C1=NCC(c2cc3ccccc3o2)C1 |
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| Storage condition | 2-8℃ |
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