CAS 153086-78-3|N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)
Introduction：Basic information about CAS 153086-78-3|N-BOC-2,2′-(ethylenedioxy)bis(ethylamine), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-BOC-2,2′-(ethylenedioxy)bis(ethylamine) | ||
|---|---|---|---|
| CAS Number | 153086-78-3 | Molecular Weight | 248.319 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 365.2±27.0 °C at 760 mmHg |
| Molecular Formula | C11H24N2O4 | Melting Point | / |
| MSDS | USA | Flash Point | 174.6±23.7 °C |
Names
| Name | tert-butyl N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | PROTAC Linker 13 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 13 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | Alkyl/ether |
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 365.2±27.0 °C at 760 mmHg |
| Molecular Formula | C11H24N2O4 |
| Molecular Weight | 248.319 |
| Flash Point | 174.6±23.7 °C |
| Exact Mass | 248.173615 |
| PSA | 82.81000 |
| LogP | 0.19 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.460 |
| InChIKey | OCUICOFGFQENAS-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCOCCOCCN |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles4
More Articles| A modular cross-linking approach for exploring protein interactions. J. Am. Chem. Soc. 125 , 2416 - 2425, (2003) A method is described for the elucidation of protein-protein interactions using novel cross-linking reagents and mass spectrometry. The method incorporates (1) a modular solid-phase synthetic strategy... | |
| Spinke, J., et al. J. Phys. Chem. 99(9) , 7012-7019, (1993) | |
| Sigal, G. B., et al. J. Am. Chem. Soc. 118 , 3789-3800, (1996) |
Synonyms
| CBZ-L-Asginine-OH Hydrochloride |
| AmbotzBNN1016 |
| 2-Methyl-2-propanyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate |
| N-BOC-2,2′-(ethylenedioxy)bis(ethylamine) |
| Carbamic acid, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester |
| N-Boc-3,6-dioxa-1,8-octanediamine |
| N-Boc-3,6-dioxaoctane-1,8-diamine |
| t-Boc-N-amido-PEG2-Amine |
